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Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.
Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. Sheikh F, et al. Among authors: lyon rc. J Clin Invest. 2012 Apr;122(4):1209-21. doi: 10.1172/JCI61134. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426213 Free PMC article.
Mechanotransduction in cardiac hypertrophy and failure.
Lyon RC, Zanella F, Omens JH, Sheikh F. Lyon RC, et al. Circ Res. 2015 Apr 10;116(8):1462-1476. doi: 10.1161/CIRCRESAHA.116.304937. Circ Res. 2015. PMID: 25858069 Free PMC article. Review.
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. Raskin A, et al. Among authors: lyon rc. J Biol Chem. 2012 Aug 24;287(35):29273-84. doi: 10.1074/jbc.M112.372839. Epub 2012 Jul 9. J Biol Chem. 2012. PMID: 22778266 Free PMC article.
Desmosomal junctions are necessary for adult sinus node function.
Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans SM, Fowler S, Cerrone M, McCulloch AD, Sheikh F. Mezzano V, et al. Among authors: lyon rc. Cardiovasc Res. 2016 Aug 1;111(3):274-86. doi: 10.1093/cvr/cvw083. Epub 2016 Apr 20. Cardiovasc Res. 2016. PMID: 27097650 Free PMC article.
55 results