Hirokawa T - Search Results

1

Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.

Akimoto T, Masuda A, Yotsu-Yamashita M, Hirokawa T, Nagasawa K. Akimoto T, et al. Among authors: hirokawa t. Org Biomol Chem. 2013 Oct 14;11(38):6642-9. doi: 10.1039/c3ob41398e. Epub 2013 Aug 30. Org Biomol Chem. 2013. PMID: 23989458

2

G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer.

Iida K, Tera M, Hirokawa T, Shin-ya K, Nagasawa K. Iida K, et al. Among authors: hirokawa t. Chem Commun (Camb). 2009 Nov 14;(42):6481-3. doi: 10.1039/b910242f. Epub 2009 Sep 14. Chem Commun (Camb). 2009. PMID: 19841816

3

Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties.

Iida K, Tera M, Hirokawa T, Shin-Ya K, Nagasawa K. Iida K, et al. Among authors: hirokawa t. J Nucleic Acids. 2010;2010:217627. doi: 10.4061/2010/217627. Epub 2010 May 24. J Nucleic Acids. 2010. PMID: 20700415 Free PMC article.

4

Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.

Shinohara R, Akimoto T, Iwamoto O, Hirokawa T, Yotsu-Yamashita M, Yamaoka K, Nagasawa K. Shinohara R, et al. Among authors: hirokawa t. Chemistry. 2011 Oct 17;17(43):12144-52. doi: 10.1002/chem.201101058. Epub 2011 Sep 16. Chemistry. 2011. PMID: 21922571

5

Synthesis of vitamin D3 derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity.

Abe J, Nagai Y, Higashikuni R, Iida K, Hirokawa T, Nagai H, Kominato K, Tsuchida T, Hirata M, Inada M, Miyaura C, Nagasawa K. Abe J, et al. Among authors: hirokawa t. Org Biomol Chem. 2012 Oct 14;10(38):7826-39. doi: 10.1039/c2ob26017d. Org Biomol Chem. 2012. PMID: 22930071

6

Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with an ability to induce distinct G-quadruplex topologies in telomeric DNA.

Sakuma M, Ma Y, Tsushima Y, Iida K, Hirokawa T, Nagasawa K. Sakuma M, et al. Among authors: hirokawa t. Org Biomol Chem. 2016 Jun 14;14(22):5109-16. doi: 10.1039/c6ob00437g. Epub 2016 May 16. Org Biomol Chem. 2016. PMID: 27181296

7

Development of G-quadruplex ligands for selective induction of a parallel-type topology.

Ma Y, Tsushima Y, Sakuma M, Sasaki S, Iida K, Okabe S, Seimiya H, Hirokawa T, Nagasawa K. Ma Y, et al. Among authors: hirokawa t. Org Biomol Chem. 2018 Oct 17;16(40):7375-7382. doi: 10.1039/c8ob01702f. Org Biomol Chem. 2018. PMID: 30187070

8

Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains.

Ma Y, Iida K, Sasaki S, Hirokawa T, Heddi B, Phan AT, Nagasawa K. Ma Y, et al. Among authors: hirokawa t. Molecules. 2019 Jan 11;24(2):263. doi: 10.3390/molecules24020263. Molecules. 2019. PMID: 30642002 Free PMC article.

9

Synthesis of C12-Keto Saxitoxin Derivatives with Unusual Inhibitory Activity Against Voltage-Gated Sodium Channels.

Adachi K, Yamada T, Ishizuka H, Oki M, Tsunogae S, Shimada N, Chiba O, Orihara T, Hidaka M, Hirokawa T, Odagi M, Konoki K, Yotsu-Yamashita M, Nagasawa K. Adachi K, et al. Among authors: hirokawa t. Chemistry. 2020 Feb 11;26(9):2025-2033. doi: 10.1002/chem.201904184. Epub 2020 Feb 3. Chemistry. 2020. PMID: 31769085

10

Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand.

Ma Y, Wakabayashi Y, Watatani N, Saito R, Hirokawa T, Tera M, Nagasawa K. Ma Y, et al. Among authors: hirokawa t. Org Biomol Chem. 2021 Sep 29;19(37):8035-8040. doi: 10.1039/d1ob01500a. Org Biomol Chem. 2021. PMID: 34492672

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