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Page 1
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, Veit F, Scheibe S, Pichl A, Weisel F, Lloyd KC, Jaksch P, Klepetko W, Weissmann N, von Melchner H. Heidler J, et al. Among authors: klepetko w. Dis Model Mech. 2013 Nov;6(6):1378-87. doi: 10.1242/dmm.013482. Epub 2013 Aug 29. Dis Model Mech. 2013. PMID: 24046361 Free PMC article.
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD.
Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI, Scheibe S, Fysikopoulos A, Wu CY, Klepetko W, Jaksch P, Eichstaedt C, Grünig E, Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M, Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A, Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K, Grimminger F, Brandes RP, Weissmann N. Seimetz M, et al. Among authors: klepetko w. Nat Metab. 2020 Jun;2(6):532-546. doi: 10.1038/s42255-020-0215-8. Epub 2020 Jun 8. Nat Metab. 2020. PMID: 32694733
Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema.
Weissmann N, Lobo B, Pichl A, Parajuli N, Seimetz M, Puig-Pey R, Ferrer E, Peinado VI, Domínguez-Fandos D, Fysikopoulos A, Stasch JP, Ghofrani HA, Coll-Bonfill N, Frey R, Schermuly RT, García-Lucio J, Blanco I, Bednorz M, Tura-Ceide O, Tadele E, Brandes RP, Grimminger J, Klepetko W, Jaksch P, Rodriguez-Roisin R, Seeger W, Grimminger F, Barberà JA. Weissmann N, et al. Among authors: klepetko w. Am J Respir Crit Care Med. 2014 Jun 1;189(11):1359-73. doi: 10.1164/rccm.201311-2037OC. Am J Respir Crit Care Med. 2014. PMID: 24738736
Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice.
Seimetz M, Parajuli N, Pichl A, Veit F, Kwapiszewska G, Weisel FC, Milger K, Egemnazarov B, Turowska A, Fuchs B, Nikam S, Roth M, Sydykov A, Medebach T, Klepetko W, Jaksch P, Dumitrascu R, Garn H, Voswinckel R, Kostin S, Seeger W, Schermuly RT, Grimminger F, Ghofrani HA, Weissmann N. Seimetz M, et al. Among authors: klepetko w. Cell. 2011 Oct 14;147(2):293-305. doi: 10.1016/j.cell.2011.08.035. Cell. 2011. PMID: 22000010 Free article.
Author Correction: NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD.
Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI, Scheibe S, Fysikopoulos A, Wu CY, Klepetko W, Jaksch P, Eichstaedt C, Grünig E, Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M, Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A, Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K, Grimminger F, Brandes RP, Weissmann N. Seimetz M, et al. Among authors: klepetko w. Nat Metab. 2020 Jul;2(7):648. doi: 10.1038/s42255-020-0248-z. Nat Metab. 2020. PMID: 32694792
Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.
Weisel FC, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, Roth M, Ridge KM, Igarashi K, Nishimura K, Maison W, Wackendorff C, Klepetko W, Jaksch P, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G. Weisel FC, et al. Among authors: klepetko w. Circulation. 2014 Apr 8;129(14):1510-23. doi: 10.1161/CIRCULATIONAHA.113.006402. Epub 2014 Jan 27. Circulation. 2014. PMID: 24470481
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.
Mittal M, Roth M, König P, Hofmann S, Dony E, Goyal P, Selbitz AC, Schermuly RT, Ghofrani HA, Kwapiszewska G, Kummer W, Klepetko W, Hoda MA, Fink L, Hänze J, Seeger W, Grimminger F, Schmidt HH, Weissmann N. Mittal M, et al. Among authors: klepetko w. Circ Res. 2007 Aug 3;101(3):258-67. doi: 10.1161/CIRCRESAHA.107.148015. Epub 2007 Jun 21. Circ Res. 2007. PMID: 17585072
638 results