Chien JY - Search Results

1

Evaluation of various static in vitro-in vivo extrapolation models for risk assessment of the CYP3A inhibition potential of an investigational drug.

Vieira ML, Kirby B, Ragueneau-Majlessi I, Galetin A, Chien JY, Einolf HJ, Fahmi OA, Fischer V, Fretland A, Grime K, Hall SD, Higgs R, Plowchalk D, Riley R, Seibert E, Skordos K, Snoeys J, Venkatakrishnan K, Waterhouse T, Obach RS, Berglund EG, Zhang L, Zhao P, Reynolds KS, Huang SM. Vieira ML, et al. Among authors: chien jy. Clin Pharmacol Ther. 2014 Feb;95(2):189-98. doi: 10.1038/clpt.2013.187. Epub 2013 Sep 18. Clin Pharmacol Ther. 2014. PMID: 24048277

2

Optimization of drug-drug interaction study design: comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole.

Han B, Mao J, Chien JY, Hall SD. Han B, et al. Among authors: chien jy. Drug Metab Dispos. 2013 Jul;41(7):1329-38. doi: 10.1124/dmd.112.050732. Epub 2013 Apr 12. Drug Metab Dispos. 2013. PMID: 23584886

3

Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole.

Chien JY, Lucksiri A, Ernest CS 2nd, Gorski JC, Wrighton SA, Hall SD. Chien JY, et al. Drug Metab Dispos. 2006 Jul;34(7):1208-19. doi: 10.1124/dmd.105.008730. Epub 2006 Apr 12. Drug Metab Dispos. 2006. PMID: 16611859

4

A new probabilistic rule for drug-dug interaction prediction.

Zhou J, Qin Z, Quinney SK, Kim S, Wang Z, Yu M, Chien JY, Lucksiri A, Hall SD, Li L. Zhou J, et al. Among authors: chien jy. J Pharmacokinet Pharmacodyn. 2009 Feb;36(1):1-18. doi: 10.1007/s10928-008-9107-3. Epub 2009 Jan 21. J Pharmacokinet Pharmacodyn. 2009. PMID: 19156505 Free PMC article.

5

Development and Qualification of a Drug-Disease Modeling Platform to Characterize Clinically Relevant Endpoints in Type 2 Diabetes Trials.

Gaitonde P, Hurtado FK, Garhyan P, Chien JY, Schmidt S. Gaitonde P, et al. Among authors: chien jy. Clin Pharmacol Ther. 2018 Oct;104(4):699-708. doi: 10.1002/cpt.998. Epub 2018 Feb 1. Clin Pharmacol Ther. 2018. PMID: 29271001

6

A Quantitative Modeling and Simulation Framework to Support Candidate and Dose Selection of Anti-SARS-CoV-2 Monoclonal Antibodies to Advance Bamlanivimab Into a First-in-Human Clinical Trial.

Chigutsa E, Jordie E, Riggs M, Nirula A, Elmokadem A, Knab T, Chien JY. Chigutsa E, et al. Among authors: chien jy. Clin Pharmacol Ther. 2022 Mar;111(3):595-604. doi: 10.1002/cpt.2459. Epub 2021 Nov 17. Clin Pharmacol Ther. 2022. PMID: 34687040 Free PMC article.

7

Population Pharmacokinetics and Pharmacodynamics of the Neutralizing Antibodies Bamlanivimab and Etesevimab in Patients With Mild to Moderate COVID-19 Infection.

Chigutsa E, O'Brien L, Ferguson-Sells L, Long A, Chien J. Chigutsa E, et al. Clin Pharmacol Ther. 2021 Nov;110(5):1302-1310. doi: 10.1002/cpt.2420. Epub 2021 Sep 24. Clin Pharmacol Ther. 2021. PMID: 34514598 Free PMC article. Clinical Trial.

8

Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid.

Chien JY, Peter RM, Nolan CM, Wartell C, Slattery JT, Nelson SD, Carithers RL Jr, Thummel KE. Chien JY, et al. Clin Pharmacol Ther. 1997 Jan;61(1):24-34. doi: 10.1016/S0009-9236(97)90179-X. Clin Pharmacol Ther. 1997. PMID: 9024171 Clinical Trial.

9

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance.

Ring BJ, Chien JY, Adkison KK, Jones HM, Rowland M, Jones RD, Yates JW, Ku MS, Gibson CR, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Poulin P. Ring BJ, et al. Among authors: chien jy. J Pharm Sci. 2011 Oct;100(10):4090-110. doi: 10.1002/jps.22552. Epub 2011 May 3. J Pharm Sci. 2011. PMID: 21541938

10

Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug-drug interaction trials.

Gueorguieva I, Jackson K, Wrighton SA, Sinha VP, Chien JY. Gueorguieva I, et al. Among authors: chien jy. Br J Clin Pharmacol. 2010 Oct;70(4):523-36. doi: 10.1111/j.1365-2125.2010.03731.x. Br J Clin Pharmacol. 2010. PMID: 20840444 Free PMC article.

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