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Evaluation of various static in vitro-in vivo extrapolation models for risk assessment of the CYP3A inhibition potential of an investigational drug.
Vieira ML, Kirby B, Ragueneau-Majlessi I, Galetin A, Chien JY, Einolf HJ, Fahmi OA, Fischer V, Fretland A, Grime K, Hall SD, Higgs R, Plowchalk D, Riley R, Seibert E, Skordos K, Snoeys J, Venkatakrishnan K, Waterhouse T, Obach RS, Berglund EG, Zhang L, Zhao P, Reynolds KS, Huang SM. Vieira ML, et al. Among authors: seibert e. Clin Pharmacol Ther. 2014 Feb;95(2):189-98. doi: 10.1038/clpt.2013.187. Epub 2013 Sep 18. Clin Pharmacol Ther. 2014. PMID: 24048277
The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America.
Grimm SW, Einolf HJ, Hall SD, He K, Lim HK, Ling KH, Lu C, Nomeir AA, Seibert E, Skordos KW, Tonn GR, Van Horn R, Wang RW, Wong YN, Yang TJ, Obach RS. Grimm SW, et al. Among authors: seibert e. Drug Metab Dispos. 2009 Jul;37(7):1355-70. doi: 10.1124/dmd.109.026716. Epub 2009 Apr 9. Drug Metab Dispos. 2009. PMID: 19359406
Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: in vitro and in vivo correlation.
Sabo JP, Kort J, Ballow C, Kashuba AD, Haschke M, Battegay M, Girlich B, Ting N, Lang B, Zhang W, Cooper C, O'Brien D, Seibert E, Chan TS, Tweedie D, Li Y. Sabo JP, et al. Among authors: seibert e. J Clin Pharmacol. 2015 Apr;55(4):467-77. doi: 10.1002/jcph.436. Epub 2015 Jan 14. J Clin Pharmacol. 2015. PMID: 25449227 Clinical Trial.
Different enzyme kinetic models.
Seibert E, Tracy TS. Seibert E, et al. Methods Mol Biol. 2014;1113:23-35. doi: 10.1007/978-1-62703-758-7_3. Methods Mol Biol. 2014. PMID: 24523107 Review.
Fundamentals of enzyme kinetics.
Seibert E, Tracy TS. Seibert E, et al. Methods Mol Biol. 2014;1113:9-22. doi: 10.1007/978-1-62703-758-7_2. Methods Mol Biol. 2014. PMID: 24523106 Review.
Molecular dynamics simulations of the 136 unique tetranucleotide sequences of DNA oligonucleotides. I. Research design and results on d(CpG) steps.
Beveridge DL, Barreiro G, Byun KS, Case DA, Cheatham TE 3rd, Dixit SB, Giudice E, Lankas F, Lavery R, Maddocks JH, Osman R, Seibert E, Sklenar H, Stoll G, Thayer KM, Varnai P, Young MA. Beveridge DL, et al. Among authors: seibert e. Biophys J. 2004 Dec;87(6):3799-813. doi: 10.1529/biophysj.104.045252. Epub 2004 Aug 23. Biophys J. 2004. PMID: 15326025 Free PMC article.
79 results