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Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: arisawa m. Bioorg Med Chem. 2013 Nov 1;21(21):6506-22. doi: 10.1016/j.bmc.2013.08.036. Epub 2013 Aug 28. Bioorg Med Chem. 2013. PMID: 24051074
Synthesis of 2,3- and 3,4-methanoamino acid equivalents with stereochemical diversity and their conversion into the tripeptide proteasome inhibitor belactosin a and its highly potent cis-cyclopropane stereoisomer.
Yoshida K, Yamaguchi K, Sone T, Unno Y, Asai A, Yokosawa H, Matsuda A, Arisawa M, Shuto S. Yoshida K, et al. Among authors: arisawa m. Org Lett. 2008 Aug 21;10(16):3571-4. doi: 10.1021/ol8013304. Epub 2008 Jul 19. Org Lett. 2008. PMID: 18642830
Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy.
Yoshida K, Yamaguchi K, Mizuno A, Unno Y, Asai A, Sone T, Yokosawa H, Matsuda A, Arisawa M, Shuto S. Yoshida K, et al. Among authors: arisawa m. Org Biomol Chem. 2009 May 7;7(9):1868-77. doi: 10.1039/b900384c. Epub 2009 Mar 12. Org Biomol Chem. 2009. PMID: 19590782
385 results