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Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.
Khanna A, Kauko O, Böckelman C, Laine A, Schreck I, Partanen JI, Szwajda A, Bormann S, Bilgen T, Helenius M, Pokharel YR, Pimanda J, Russel MR, Haglund C, Cole KA, Klefström J, Aittokallio T, Weiss C, Ristimäki A, Visakorpi T, Westermarck J. Khanna A, et al. Among authors: westermarck j. Cancer Res. 2013 Nov 15;73(22):6757-69. doi: 10.1158/0008-5472.CAN-13-1002. Epub 2013 Sep 26. Cancer Res. 2013. PMID: 24072747 Free PMC article.
CIP2A inhibits PP2A in human malignancies.
Junttila MR, Puustinen P, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grènman R, Kast J, Kallunki T, Sears R, Kähäri VM, Westermarck J. Junttila MR, et al. Among authors: westermarck j. Cell. 2007 Jul 13;130(1):51-62. doi: 10.1016/j.cell.2007.04.044. Cell. 2007. PMID: 17632056 Free article.
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.
Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, Haapasalo H, Hahn WC, Westermarck J. Puustinen P, et al. Among authors: westermarck j. Cancer Res. 2009 Apr 1;69(7):2870-7. doi: 10.1158/0008-5472.CAN-08-2760. Epub 2009 Mar 17. Cancer Res. 2009. PMID: 19293187 Free PMC article.
MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.
Khanna A, Böckelman C, Hemmes A, Junttila MR, Wiksten JP, Lundin M, Junnila S, Murphy DJ, Evan GI, Haglund C, Westermarck J, Ristimäki A. Khanna A, et al. Among authors: westermarck j. J Natl Cancer Inst. 2009 Jun 3;101(11):793-805. doi: 10.1093/jnci/djp103. Epub 2009 May 26. J Natl Cancer Inst. 2009. PMID: 19470954
CIP2A is associated with human breast cancer aggressivity.
Côme C, Laine A, Chanrion M, Edgren H, Mattila E, Liu X, Jonkers J, Ivaska J, Isola J, Darbon JM, Kallioniemi O, Thézenas S, Westermarck J. Côme C, et al. Among authors: westermarck j. Clin Cancer Res. 2009 Aug 15;15(16):5092-100. doi: 10.1158/1078-0432.CCR-08-3283. Epub 2009 Aug 11. Clin Cancer Res. 2009. PMID: 19671842
CIP2A increases self-renewal and is linked to Myc in neural progenitor cells.
Kerosuo L, Fox H, Perälä N, Ahlqvist K, Suomalainen A, Westermarck J, Sariola H, Wartiovaara K. Kerosuo L, et al. Among authors: westermarck j. Differentiation. 2010 Jul;80(1):68-77. doi: 10.1016/j.diff.2010.04.003. Epub 2010 May 5. Differentiation. 2010. PMID: 20447748
120 results