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Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH. Garris CS, et al. Among authors: axtell rc. Nat Immunol. 2013 Nov;14(11):1166-72. doi: 10.1038/ni.2730. Epub 2013 Sep 29. Nat Immunol. 2013. PMID: 24076635 Free PMC article.
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.
Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C. Axtell RC, et al. Nat Med. 2010 Apr;16(4):406-12. doi: 10.1038/nm.2110. Epub 2010 Mar 28. Nat Med. 2010. PMID: 20348925 Free PMC article.
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. Han MH, et al. Among authors: axtell rc. J Exp Med. 2012 Jul 2;209(7):1325-34. doi: 10.1084/jem.20101974. Epub 2012 Jun 25. J Exp Med. 2012. PMID: 22734047 Free PMC article.
Type 1 interferons cool the inflamed brain.
Axtell RC, Steinman L. Axtell RC, et al. Immunity. 2008 May;28(5):600-2. doi: 10.1016/j.immuni.2008.04.006. Immunity. 2008. PMID: 18482563 Free article.
Gaining entry to an uninflamed brain.
Axtell RC, Steinman L. Axtell RC, et al. Nat Immunol. 2009 May;10(5):453-5. doi: 10.1038/ni0509-453. Nat Immunol. 2009. PMID: 19381137 No abstract available.
135 results