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Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases.
Proschak A, Martinelli G, Frank D, Rotter MJ, Brunst S, Weizel L, Burgers LD, Fürst R, Proschak E, Sosič I, Gobec S, Wichelhaus TA. Proschak A, et al. Among authors: wichelhaus ta. Eur J Med Chem. 2022 Jan 15;228:113975. doi: 10.1016/j.ejmech.2021.113975. Epub 2021 Nov 13. Eur J Med Chem. 2022. PMID: 34865870
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases.
Kaya C, Konstantinović J, Kany AM, Andreas A, Kramer JS, Brunst S, Weizel L, Rotter MJ, Frank D, Yahiaoui S, Müller R, Hartmann RW, Haupenthal J, Proschak E, Wichelhaus TA, Hirsch AKH. Kaya C, et al. Among authors: wichelhaus ta. J Med Chem. 2022 Mar 10;65(5):3913-3922. doi: 10.1021/acs.jmedchem.1c01755. Epub 2022 Feb 21. J Med Chem. 2022. PMID: 35188771
RhII -Catalyzed De-symmetrization of Ethane-1,2-dithiol and Propane-1,3-dithiol Yields Metallo-β-lactamase Inhibitors.
Krasavin M, Zhukovsky D, Solovyev I, Barkhatova D, Dar'in D, Frank D, Martinelli G, Weizel L, Proschak A, Rotter M, Kramer JS, Brunst S, Wichelhaus TA, Proschak E. Krasavin M, et al. Among authors: wichelhaus ta. ChemMedChem. 2021 Nov 19;16(22):3410-3417. doi: 10.1002/cmdc.202100344. Epub 2021 Aug 3. ChemMedChem. 2021. PMID: 34184833 Free PMC article.
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa.
Yahiaoui S, Voos K, Haupenthal J, Wichelhaus TA, Frank D, Weizel L, Rotter M, Brunst S, Kramer JS, Proschak E, Ducho C, Hirsch AKH. Yahiaoui S, et al. Among authors: wichelhaus ta. RSC Med Chem. 2021 Jul 29;12(10):1698-1708. doi: 10.1039/d1md00187f. eCollection 2021 Oct 20. RSC Med Chem. 2021. PMID: 34778771 Free PMC article.
148 results