Hatton D - Search Results

1

A high-yielding CHO transient system: coexpression of genes encoding EBNA-1 and GS enhances transient protein expression.

Daramola O, Stevenson J, Dean G, Hatton D, Pettman G, Holmes W, Field R. Daramola O, et al. Among authors: hatton d. Biotechnol Prog. 2014 Jan-Feb;30(1):132-41. doi: 10.1002/btpr.1809. Epub 2013 Oct 10. Biotechnol Prog. 2014. PMID: 24106171

2

Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture.

Bailey LA, Hatton D, Field R, Dickson AJ. Bailey LA, et al. Among authors: hatton d. Biotechnol Bioeng. 2012 Aug;109(8):2093-103. doi: 10.1002/bit.24485. Biotechnol Bioeng. 2012. PMID: 22896849

3

N-terminal or signal peptide sequence engineering prevents truncation of human monoclonal antibody light chains.

Gibson SJ, Bond NJ, Milne S, Lewis A, Sheriff A, Pettman G, Pradhan R, Higazi DR, Hatton D. Gibson SJ, et al. Among authors: hatton d. Biotechnol Bioeng. 2017 Sep;114(9):1970-1977. doi: 10.1002/bit.26301. Epub 2017 May 8. Biotechnol Bioeng. 2017. PMID: 28369727

4

Polysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRNA loading onto ribosomes with global and recombinant protein synthesis.

Godfrey CL, Mead EJ, Daramola O, Dunn S, Hatton D, Field R, Pettman G, Smales CM. Godfrey CL, et al. Among authors: hatton d. Biotechnol J. 2017 Aug;12(8). doi: 10.1002/biot.201700177. Epub 2017 Jul 5. Biotechnol J. 2017. PMID: 28504349

5

New Mammalian Expression Systems.

Zhu J, Hatton D. Zhu J, et al. Among authors: hatton d. Adv Biochem Eng Biotechnol. 2018;165:9-50. doi: 10.1007/10_2016_55. Adv Biochem Eng Biotechnol. 2018. PMID: 28585079 Review.

6

Transcriptome-Based Identification of the Optimal Reference CHO Genes for Normalisation of qPCR Data.

Brown AJ, Gibson S, Hatton D, James DC. Brown AJ, et al. Among authors: hatton d. Biotechnol J. 2018 Jan;13(1). doi: 10.1002/biot.201700259. Epub 2017 Sep 29. Biotechnol J. 2018. PMID: 28731643 Free article.

7

A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies.

Roy G, Martin T, Barnes A, Wang J, Jimenez RB, Rice M, Li L, Feng H, Zhang S, Chaerkady R, Wu H, Marelli M, Hatton D, Zhu J, Bowen MA. Roy G, et al. Among authors: hatton d. MAbs. 2018 Apr;10(3):416-430. doi: 10.1080/19420862.2018.1433975. Epub 2018 Feb 22. MAbs. 2018. PMID: 29400603 Free PMC article.

8

Control of amino acid transport into Chinese hamster ovary cells.

Geoghegan D, Arnall C, Hatton D, Noble-Longster J, Sellick C, Senussi T, James DC. Geoghegan D, et al. Among authors: hatton d. Biotechnol Bioeng. 2018 Dec;115(12):2908-2929. doi: 10.1002/bit.26794. Epub 2018 Oct 5. Biotechnol Bioeng. 2018. PMID: 29987891

9

Whole synthetic pathway engineering of recombinant protein production.

Brown AJ, Gibson SJ, Hatton D, Arnall CL, James DC. Brown AJ, et al. Among authors: hatton d. Biotechnol Bioeng. 2019 Feb;116(2):375-387. doi: 10.1002/bit.26855. Epub 2018 Nov 5. Biotechnol Bioeng. 2019. PMID: 30345502 Free article.

10

Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics.

Agarwal N, Mason A, Pradhan R, Kemper J, Bosley A, Serfiotis-Mitsa D, Wang J, Lindo V, Ahuja S, Hatton D, Savery J, Miro-Quesada G. Agarwal N, et al. Among authors: hatton d. Biotechnol Prog. 2019 Sep;35(5):e2865. doi: 10.1002/btpr.2865. Epub 2019 Jun 21. Biotechnol Prog. 2019. PMID: 31180183

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