Harden TK - Search Results

1

Enigmatic GPCR finds a stimulating drug.

Harden TK. Harden TK. Sci Signal. 2013 Oct 22;6(298):pe34. doi: 10.1126/scisignal.2004755. Sci Signal. 2013. PMID: 24150253

2

Small molecule inhibitors of phospholipase C from a novel high-throughput screen.

Huang W, Barrett M, Hajicek N, Hicks S, Harden TK, Sondek J, Zhang Q. Huang W, et al. Among authors: harden tk. J Biol Chem. 2013 Feb 22;288(8):5840-8. doi: 10.1074/jbc.M112.422501. Epub 2013 Jan 7. J Biol Chem. 2013. PMID: 23297405 Free PMC article.

3

Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17.

Qi AD, Harden TK, Nicholas RA. Qi AD, et al. Among authors: harden tk. J Pharmacol Exp Ther. 2013 Oct;347(1):38-46. doi: 10.1124/jpet.113.207647. Epub 2013 Aug 1. J Pharmacol Exp Ther. 2013. PMID: 23908386 Free PMC article.

4

Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.

Fricks IP, Carter RL, Lazarowski ER, Harden TK. Fricks IP, et al. Among authors: harden tk. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8. doi: 10.1124/jpet.109.150730. Epub 2009 Apr 1. J Pharmacol Exp Ther. 2009. PMID: 19339661 Free PMC article.

5

Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.

Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK. Carter RL, et al. Among authors: harden tk. Mol Pharmacol. 2009 Dec;76(6):1341-8. doi: 10.1124/mol.109.058578. Epub 2009 Sep 16. Mol Pharmacol. 2009. PMID: 19759354 Free PMC article.

6

The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses.

Li Q, Schachter JB, Harden TK, Nicholas RA. Li Q, et al. Among authors: harden tk. Biochem Biophys Res Commun. 1997 Jul 18;236(2):455-60. doi: 10.1006/bbrc.1997.6984. Biochem Biophys Res Commun. 1997. PMID: 9240460

7

Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.

Chhatriwala M, Ravi RG, Patel RI, Boyer JL, Jacobson KA, Harden TK. Chhatriwala M, et al. Among authors: harden tk. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43. doi: 10.1124/jpet.104.068650. Epub 2004 Sep 2. J Pharmacol Exp Ther. 2004. PMID: 15345752 Free PMC article.

8

Signalling and pharmacological properties of the P2Y receptor.

Harden TK, Sesma JI, Fricks IP, Lazarowski ER. Harden TK, et al. Acta Physiol (Oxf). 2010 Jun;199(2):149-60. doi: 10.1111/j.1748-1716.2010.02116.x. Epub 2010 Mar 24. Acta Physiol (Oxf). 2010. PMID: 20345417 Free PMC article. Review.

9

Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor.

Waldo GL, Harden TK. Waldo GL, et al. Among authors: harden tk. Mol Pharmacol. 2004 Feb;65(2):426-36. doi: 10.1124/mol.65.2.426. Mol Pharmacol. 2004. PMID: 14742685

10

The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.

Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER. Sesma JI, et al. Among authors: harden tk. Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C490-8. doi: 10.1152/ajpcell.00138.2012. Epub 2012 Jun 6. Am J Physiol Cell Physiol. 2012. PMID: 22673622 Free PMC article.

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