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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J. Hildebrand JM, et al. Among authors: sharma p. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. doi: 10.1073/pnas.1408987111. Epub 2014 Oct 6. Proc Natl Acad Sci U S A. 2014. PMID: 25288762 Free PMC article.
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway.
Pierotti CL, Tanzer MC, Jacobsen AV, Hildebrand JM, Garnier JM, Sharma P, Lucet IS, Cowan AD, Kersten WJA, Luo MX, Liang LY, Fitzgibbon C, Garnish SE, Hempel A, Nachbur U, Huang DCS, Czabotar PE, Silke J, van Delft MF, Murphy JM, Lessene G. Pierotti CL, et al. Among authors: sharma p. ACS Chem Biol. 2020 Oct 16;15(10):2702-2713. doi: 10.1021/acschembio.0c00482. Epub 2020 Sep 22. ACS Chem Biol. 2020. PMID: 32902249
The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes.
Paxman JJ, Borg NA, Horne J, Thompson PE, Chin Y, Sharma P, Simpson JS, Wielens J, Piek S, Kahler CM, Sakellaris H, Pearce M, Bottomley SP, Rossjohn J, Scanlon MJ. Paxman JJ, et al. Among authors: sharma p. J Biol Chem. 2009 Jun 26;284(26):17835-45. doi: 10.1074/jbc.M109.011502. Epub 2009 Apr 22. J Biol Chem. 2009. PMID: 19389711 Free PMC article.
Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens.
Totsika M, Vagenas D, Paxman JJ, Wang G, Dhouib R, Sharma P, Martin JL, Scanlon MJ, Heras B. Totsika M, et al. Among authors: sharma p. Antioxid Redox Signal. 2018 Sep 1;29(7):653-666. doi: 10.1089/ars.2017.7104. Epub 2018 Feb 1. Antioxid Redox Signal. 2018. PMID: 29237285 Free PMC article.
Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA.
Adams LA, Sharma P, Mohanty B, Ilyichova OV, Mulcair MD, Williams ML, Gleeson EC, Totsika M, Doak BC, Caria S, Rimmer K, Horne J, Shouldice SR, Vazirani M, Headey SJ, Plumb BR, Martin JL, Heras B, Simpson JS, Scanlon MJ. Adams LA, et al. Among authors: sharma p. Angew Chem Int Ed Engl. 2015 Feb 9;54(7):2179-84. doi: 10.1002/anie.201410341. Epub 2014 Dec 30. Angew Chem Int Ed Engl. 2015. PMID: 25556635
Immigration Status Checks, Emergency Medicaid Utilization, and Health Care Access for Uninsured Individuals with Kidney Disease.
Rizzolo K, Murray R, Teakell J, Kerns E, Acharya P, Patel P, Sharma P, Cervantes L; Expanding Access to Kidney Care for Uninsured Individuals Workgroup of the ASN Health Care Justice Committee. Rizzolo K, et al. Among authors: sharma p. J Am Soc Nephrol. 2024 Dec 2. doi: 10.1681/ASN.0000000589. Online ahead of print. J Am Soc Nephrol. 2024. PMID: 39621432 No abstract available.
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