Brady SW - Search Results

1

Enhanced PI3K p110α signaling confers acquired lapatinib resistance that can be effectively reversed by a p110α-selective PI3K inhibitor.

Brady SW, Zhang J, Seok D, Wang H, Yu D. Brady SW, et al. Mol Cancer Ther. 2014 Jan;13(1):60-70. doi: 10.1158/1535-7163.MCT-13-0518. Epub 2013 Nov 18. Mol Cancer Ther. 2014. PMID: 24249715 Free PMC article.

2

Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer.

Wang Q, Li SH, Wang H, Xiao Y, Sahin O, Brady SW, Li P, Ge H, Jaffee EM, Muller WJ, Hortobagyi GN, Yu D. Wang Q, et al. Among authors: brady sw. Cancer Res. 2012 Sep 1;72(17):4417-28. doi: 10.1158/0008-5472.CAN-12-1339-T. Epub 2012 Jul 6. Cancer Res. 2012. PMID: 22773664 Free PMC article.

3

PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition.

Brady SW, Zhang J, Tsai MH, Yu D. Brady SW, et al. Cancer Biol Ther. 2015;16(3):402-11. doi: 10.1080/15384047.2014.1002693. Cancer Biol Ther. 2015. PMID: 25692408 Free PMC article.

4

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer.

Jain S, Wang X, Chang CC, Ibarra-Drendall C, Wang H, Zhang Q, Brady SW, Li P, Zhao H, Dobbs J, Kyrish M, Tkaczyk TS, Ambrose A, Sistrunk C, Arun BK, Richards-Kortum R, Jia W, Seewaldt VL, Yu D. Jain S, et al. Among authors: brady sw. Cancer Res. 2015 Nov 15;75(22):4863-75. doi: 10.1158/0008-5472.CAN-14-2345. Epub 2015 Sep 17. Cancer Res. 2015. PMID: 26383165 Free PMC article.

5

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways.

Zhang S, Huang WC, Li P, Guo H, Poh SB, Brady SW, Xiong Y, Tseng LM, Li SH, Ding Z, Sahin AA, Esteva FJ, Hortobagyi GN, Yu D. Zhang S, et al. Among authors: brady sw. Nat Med. 2011 Apr;17(4):461-9. doi: 10.1038/nm.2309. Epub 2011 Mar 13. Nat Med. 2011. PMID: 21399647 Free PMC article.

6

Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors.

Sahin O, Wang Q, Brady SW, Ellis K, Wang H, Chang CC, Zhang Q, Priya P, Zhu R, Wong ST, Landis MD, Muller WJ, Esteva FJ, Chang J, Yu D. Sahin O, et al. Among authors: brady sw. Cell Res. 2014 May;24(5):542-59. doi: 10.1038/cr.2014.37. Epub 2014 Mar 28. Cell Res. 2014. PMID: 24675532 Free PMC article.

7

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.

Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ. Boulbes DR, et al. Among authors: brady sw. Mol Oncol. 2015 Mar;9(3):586-600. doi: 10.1016/j.molonc.2014.10.011. Epub 2014 Nov 11. Mol Oncol. 2015. PMID: 25435280 Free PMC article.

8

Targeting Aberrant p70S6K Activation for Estrogen Receptor-Negative Breast Cancer Prevention.

Wang X, Yao J, Wang J, Zhang Q, Brady SW, Arun B, Seewaldt VL, Yu D. Wang X, et al. Among authors: brady sw. Cancer Prev Res (Phila). 2017 Nov;10(11):641-650. doi: 10.1158/1940-6207.CAPR-17-0106. Epub 2017 Sep 6. Cancer Prev Res (Phila). 2017. PMID: 28877935 Free PMC article.

9

Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells.

Kumar A, Xu J, Brady S, Gao H, Yu D, Reuben J, Mehta K. Kumar A, et al. PLoS One. 2010 Oct 12;5(10):e13390. doi: 10.1371/journal.pone.0013390. PLoS One. 2010. PMID: 20967228 Free PMC article.

10

Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability.

Li H, Chen Y, Ding M, Liu J, Sun H, Fang H, Brady SW, Xu Y, Glaser F, Ma X, Tang Y, Du L, Wu X, Wang S, Zhu L, Li B, Shen S, Zhang J, Zheng L, Yu J, Assaraf YG, Zhou BS. Li H, et al. Among authors: brady sw. Drug Resist Updat. 2024 Nov;77:101141. doi: 10.1016/j.drup.2024.101141. Epub 2024 Aug 16. Drug Resist Updat. 2024. PMID: 39181011

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