Howell GR - Search Results

1

Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.

Jackson HM, Soto I, Graham LC, Carter GW, Howell GR. Jackson HM, et al. Among authors: howell gr. BMC Genomics. 2013 Nov 25;14:831. doi: 10.1186/1471-2164-14-831. BMC Genomics. 2013. PMID: 24274089 Free PMC article.

2

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.

Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW. Howell GR, et al. J Clin Invest. 2011 Apr;121(4):1429-44. doi: 10.1172/JCI44646. Epub 2011 Mar 7. J Clin Invest. 2011. PMID: 21383504 Free PMC article.

3

Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.

Nair KS, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW. Nair KS, et al. Among authors: howell gr. Nat Genet. 2011 Jun;43(6):579-84. doi: 10.1038/ng.813. Epub 2011 May 1. Nat Genet. 2011. PMID: 21532570 Free PMC article.

4

Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data.

Howell GR, Walton DO, King BL, Libby RT, John SW. Howell GR, et al. BMC Genomics. 2011 Aug 24;12:429. doi: 10.1186/1471-2164-12-429. BMC Genomics. 2011. PMID: 21864367 Free PMC article.

5

Intrinsic axonal degeneration pathways are critical for glaucomatous damage.

Howell GR, Soto I, Libby RT, John SW. Howell GR, et al. Exp Neurol. 2013 Aug;246:54-61. doi: 10.1016/j.expneurol.2012.01.014. Epub 2012 Jan 18. Exp Neurol. 2013. PMID: 22285251 Free PMC article. Review.

6

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.

Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, MacNicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW. Howell GR, et al. J Clin Invest. 2012 Apr;122(4):1246-61. doi: 10.1172/JCI61135. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426214 Free PMC article.

7

Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy.

Nickells RW, Howell GR, Soto I, John SW. Nickells RW, et al. Among authors: howell gr. Annu Rev Neurosci. 2012;35:153-79. doi: 10.1146/annurev.neuro.051508.135728. Epub 2012 Apr 12. Annu Rev Neurosci. 2012. PMID: 22524788 Review.

8

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.

Howell GR, Soto I, Ryan M, Graham LC, Smith RS, John SW. Howell GR, et al. J Neuroinflammation. 2013 Jun 27;10:76. doi: 10.1186/1742-2094-10-76. J Neuroinflammation. 2013. PMID: 23806181 Free PMC article.

9

The complex role of neuroinflammation in glaucoma.

Soto I, Howell GR. Soto I, et al. Among authors: howell gr. Cold Spring Harb Perspect Med. 2014 Jul 3;4(8):a017269. doi: 10.1101/cshperspect.a017269. Cold Spring Harb Perspect Med. 2014. PMID: 24993677 Free PMC article. Review.

10

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma.

Howell GR, MacNicoll KH, Braine CE, Soto I, Macalinao DG, Sousa GL, John SW. Howell GR, et al. Neurobiol Dis. 2014 Nov;71:44-52. doi: 10.1016/j.nbd.2014.07.016. Epub 2014 Aug 15. Neurobiol Dis. 2014. PMID: 25132557 Free PMC article.

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