The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system.
Coomans CP, Geerling JJ, van den Berg SA, van Diepen HC, Garcia-Tardón N, Thomas A, Schröder-van der Elst JP, Ouwens DM, Pijl H, Rensen PC, Havekes LM, Guigas B, Romijn JA.
Coomans CP, et al.
Br J Pharmacol. 2013 Oct;170(4):908-18. doi: 10.1111/bph.12338.
Br J Pharmacol. 2013.
PMID: 23957854
Free PMC article.