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[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.
Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, Yapp C, Philpott M, Martin SJ, Felletar I, Marsden BD, Filippakopoulos P, Müller S, Knapp S, Brennan PE. Fedorov O, et al. Among authors: lingard h. J Med Chem. 2014 Jan 23;57(2):462-76. doi: 10.1021/jm401568s. Epub 2013 Dec 30. J Med Chem. 2014. PMID: 24313754 Free PMC article.
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
Picaud S, Wells C, Felletar I, Brotherton D, Martin S, Savitsky P, Diez-Dacal B, Philpott M, Bountra C, Lingard H, Fedorov O, Müller S, Brennan PE, Knapp S, Filippakopoulos P. Picaud S, et al. Among authors: lingard h. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19754-9. doi: 10.1073/pnas.1310658110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248379 Free PMC article.
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, Brennan P, Muller S, Samsonova A, Gingras AC, Schwaller J, Vassiliou G, Knapp S, Filippakopoulos P. Picaud S, et al. Among authors: lingard h. Sci Adv. 2016 Oct 12;2(10):e1600760. doi: 10.1126/sciadv.1600760. eCollection 2016 Oct. Sci Adv. 2016. PMID: 27757418 Free PMC article.
A Lewis acid-mediated conformational switch.
Knipe PC, Lingard H, Jones IM, Thompson S, Hamilton AD. Knipe PC, et al. Among authors: lingard h. Org Biomol Chem. 2014 Oct 28;12(40):7937-41. doi: 10.1039/c4ob01556h. Org Biomol Chem. 2014. PMID: 25184700
A blended face-to-face and smartphone intervention to improve suicide prevention literacy and help-seeking intentions among construction workers: a randomised controlled trial.
King TL, Fleitas Alfonzo L, Batterham P, Mackinnon A, Lockwood C, Harvey S, Kelly B, Lingard H, Cox L, LaMontagne TD. King TL, et al. Among authors: lingard h. Soc Psychiatry Psychiatr Epidemiol. 2023 Jun;58(6):871-881. doi: 10.1007/s00127-023-02429-9. Epub 2023 Feb 9. Soc Psychiatry Psychiatr Epidemiol. 2023. PMID: 36757436 Free PMC article. Clinical Trial.
16 results