Laing NM - Search Results

1

Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).

Hennessy EJ, Adam A, Aquila BM, Castriotta LM, Cook D, Hattersley M, Hird AW, Huntington C, Kamhi VM, Laing NM, Li D, MacIntyre T, Omer CA, Oza V, Patterson T, Repik G, Rooney MT, Saeh JC, Sha L, Vasbinder MM, Wang H, Whitston D. Hennessy EJ, et al. Among authors: laing nm. J Med Chem. 2013 Dec 27;56(24):9897-919. doi: 10.1021/jm401075x. Epub 2013 Dec 13. J Med Chem. 2013. PMID: 24320998

2

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.

Hennessy EJ, Saeh JC, Sha L, MacIntyre T, Wang H, Larsen NA, Aquila BM, Ferguson AD, Laing NM, Omer CA. Hennessy EJ, et al. Among authors: laing nm. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1690-4. doi: 10.1016/j.bmcl.2011.12.109. Epub 2011 Dec 31. Bioorg Med Chem Lett. 2012. PMID: 22264476

3

Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.

Hird AW, Aquila BM, Block MH, Hennessy EJ, Kamhi VM, Omer CA, Laing NM, Saeh JC, Sha L, Yang B. Hird AW, et al. Among authors: laing nm. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1820-4. doi: 10.1016/j.bmcl.2014.02.016. Epub 2014 Feb 24. Bioorg Med Chem Lett. 2014. PMID: 24631189

4

A Smac mimetic augments the response of urothelial cancer cells to gemcitabine and cisplatin.

Lee EK, Jinesh G G, Laing NM, Choi W, McConkey DJ, Kamat AM. Lee EK, et al. Among authors: laing nm. Cancer Biol Ther. 2013 Sep;14(9):812-22. doi: 10.4161/cbt.25326. Epub 2013 Jun 19. Cancer Biol Ther. 2013. PMID: 23792592 Free PMC article.

5

Development of a new fully human anti-CD20 monoclonal antibody for the treatment of B-cell malignancies.

Bornstein GG, Quéva C, Tabrizi M, van Abbema A, Chavez C, Wang P, Foord O, Ahluwalia K, Laing N, Raja S, Wen S, Green LL, Yang X, Webster C, Stewart R, Blakey D. Bornstein GG, et al. Invest New Drugs. 2010 Oct;28(5):561-74. doi: 10.1007/s10637-009-9291-z. Epub 2009 Jul 21. Invest New Drugs. 2010. PMID: 19626278

6

Inhibition of platelet-derived growth factor receptor α by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancer.

Laing N, McDermott B, Wen S, Yang D, Lawson D, Collins M, Reimer C, Hall PA, Andersén H, Snaith M, Wang X, Bedian V, Cao ZA, Blakey D. Laing N, et al. Mol Pharmacol. 2013 Jun;83(6):1247-56. doi: 10.1124/mol.112.084079. Epub 2013 Apr 4. Mol Pharmacol. 2013. PMID: 23558446

7

Selective IAP inhibition results in sensitization of unstimulated but not CD40-stimulated chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis.

Zhuang J, Laing N, Oates M, Lin K, Johnson G, Pettitt AR. Zhuang J, et al. Pharmacol Res Perspect. 2014 Dec;2(6):e00081. doi: 10.1002/prp2.81. Epub 2014 Sep 1. Pharmacol Res Perspect. 2014. PMID: 25505620 Free PMC article.

8

Development and validation of a gene expression score that predicts response to fulvestrant in breast cancer patients.

Knudsen S, Jensen T, Hansen A, Mazin W, Lindemann J, Kuter I, Laing N, Anderson E. Knudsen S, et al. PLoS One. 2014 Feb 5;9(2):e87415. doi: 10.1371/journal.pone.0087415. eCollection 2014. PLoS One. 2014. PMID: 24505287 Free PMC article. Clinical Trial.

9

Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis.

Jinesh GG, Molina JR, Huang L, Laing NM, Mills GB, Bar-Eli M, Kamat AM. Jinesh GG, et al. Among authors: laing nm. Cell Death Discov. 2016 Feb 1;2:16003. doi: 10.1038/cddiscovery.2016.3. eCollection 2016. Cell Death Discov. 2016. PMID: 27551498 Free PMC article.

10

Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.

Michaud NR, Wang Y, McEachern KA, Jordan JJ, Mazzola AM, Hernandez A, Jalla S, Chesebrough JW, Hynes MJ, Belmonte MA, Wang L, Kang JS, Jovanovic J, Laing N, Jenkins DW, Hurt E, Liang M, Frantz C, Hollingsworth RE, Simeone DM, Blakey DC, Bedian V. Michaud NR, et al. Mol Cancer Ther. 2014 Feb;13(2):386-98. doi: 10.1158/1535-7163.MCT-13-0420. Epub 2013 Dec 16. Mol Cancer Ther. 2014. PMID: 24344235

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