Spanka C - Search Results

1

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists.

Porter DW, Bradley M, Brown Z, Canova R, Charlton S, Cox B, Hunt P, Kolarik D, Lewis S, O'Connor D, Reilly J, Spanka C, Tedaldi L, Watson SJ, Wermuth R, Press NJ. Porter DW, et al. Among authors: spanka c. Bioorg Med Chem Lett. 2014 Jan 1;24(1):72-6. doi: 10.1016/j.bmcl.2013.11.074. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24332493

2

Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network.

Faller B, Spanka C, Sergejew T, Tschinke V. Faller B, et al. Among authors: spanka c. J Med Chem. 2000 Apr 20;43(8):1467-75. doi: 10.1021/jm990261n. J Med Chem. 2000. PMID: 10780902

3

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.

Spanka C, Glatthar R, Desrayaud S, Fendt M, Orain D, Troxler T, Vranesic I. Spanka C, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):184-8. doi: 10.1016/j.bmcl.2009.11.001. Epub 2009 Nov 5. Bioorg Med Chem Lett. 2010. PMID: 19931453

4

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Guagnano V, Furet P, Spanka C, Bordas V, Le Douget M, Stamm C, Brueggen J, Jensen MR, Schnell C, Schmid H, Wartmann M, Berghausen J, Drueckes P, Zimmerlin A, Bussiere D, Murray J, Graus Porta D. Guagnano V, et al. Among authors: spanka c. J Med Chem. 2011 Oct 27;54(20):7066-83. doi: 10.1021/jm2006222. Epub 2011 Sep 21. J Med Chem. 2011. PMID: 21936542

5

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.

Thoma G, Markert C, Lueoend R, Miltz W, Spanka C, Bollbuck B, Wolf RM, Srinivas H, Penno CA, Kiffe M, Gajewska M, Bednarczyk D, Wieczorek G, Evans A, Beerli C, Röhn TA. Thoma G, et al. Among authors: spanka c. J Med Chem. 2023 Dec 14;66(23):16410-16425. doi: 10.1021/acs.jmedchem.3c01866. Epub 2023 Nov 28. J Med Chem. 2023. PMID: 38015154

6

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.

Yin Z, Chen YL, Kondreddi RR, Chan WL, Wang G, Ng RH, Lim JY, Lee WY, Jeyaraj DA, Niyomrattanakit P, Wen D, Chao A, Glickman JF, Voshol H, Mueller D, Spanka C, Dressler S, Nilar S, Vasudevan SG, Shi PY, Keller TH. Yin Z, et al. Among authors: spanka c. J Med Chem. 2009 Dec 24;52(24):7934-7. doi: 10.1021/jm901044z. J Med Chem. 2009. PMID: 20014868

7

Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin.

Rusch M, Thevenon A, Hoepfner D, Aust T, Studer C, Patoor M, Rollin P, Livendahl M, Ranieri B, Schmitt E, Spanka C, Gademann K, Bouchez LC. Rusch M, et al. Among authors: spanka c. Chembiochem. 2019 Mar 1;20(5):644-649. doi: 10.1002/cbic.201800587. Epub 2019 Feb 4. Chembiochem. 2019. PMID: 30462880

8

Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608.

Wiesenberg I, Chiesi M, Missbach M, Spanka C, Pignat W, Carlberg C. Wiesenberg I, et al. Among authors: spanka c. Mol Pharmacol. 1998 Jun;53(6):1131-8. Mol Pharmacol. 1998. PMID: 9614218

9

Solid-phase rhodium carbenoid reactions: an N-H insertion route to a diverse series of oxazoles.

Clapham B, Spanka C, Janda KD. Clapham B, et al. Among authors: spanka c. Org Lett. 2001 Jul 12;3(14):2173-6. doi: 10.1021/ol010075n. Org Lett. 2001. PMID: 11440572

10

A tunable hydrogel for encapsulation and controlled release of bioactive proteins.

Delgado M, Spanka C, Kerwin LD, Wentworth P Jr, Janda KD. Delgado M, et al. Among authors: spanka c. Biomacromolecules. 2002 Mar-Apr;3(2):262-71. doi: 10.1021/bm010147y. Biomacromolecules. 2002. PMID: 11888310

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