Zhang J - Search Results

1

Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors.

Wang Y, Cai W, Zhang G, Yang T, Liu Q, Cheng Y, Zhou L, Ma Y, Cheng Z, Lu S, Zhao YG, Zhang W, Xiang Z, Wang S, Yang L, Wu Q, Orband-Miller LA, Xu Y, Zhang J, Gao R, Huxdorf M, Xiang JN, Zhong Z, Elliott JD, Leung S, Lin X. Wang Y, et al. Among authors: zhang g, zhang w, zhang j. Bioorg Med Chem. 2014 Jan 15;22(2):692-702. doi: 10.1016/j.bmc.2013.12.021. Epub 2013 Dec 21. Bioorg Med Chem. 2014. PMID: 24388993

2

Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists.

Yang T, Liu Q, Cheng Y, Cai W, Ma Y, Yang L, Wu Q, Orband-Miller LA, Zhou L, Xiang Z, Huxdorf M, Zhang W, Zhang J, Xiang JN, Leung S, Qiu Y, Zhong Z, Elliott JD, Lin X, Wang Y. Yang T, et al. Among authors: zhang w, zhang j. ACS Med Chem Lett. 2013 Nov 22;5(1):65-8. doi: 10.1021/ml4003875. eCollection 2014 Jan 9. ACS Med Chem Lett. 2013. PMID: 24900774 Free PMC article.

3

Increasing human Th17 differentiation through activation of orphan nuclear receptor retinoid acid-related orphan receptor γ (RORγ) by a class of aryl amide compounds.

Zhang W, Zhang J, Fang L, Zhou L, Wang S, Xiang Z, Li Y, Wisely B, Zhang G, An G, Wang Y, Leung S, Zhong Z. Zhang W, et al. Among authors: zhang g, zhang j. Mol Pharmacol. 2012 Oct;82(4):583-90. doi: 10.1124/mol.112.078667. Epub 2012 Jun 14. Mol Pharmacol. 2012. PMID: 22700697

4

Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.

Liu Z, Zhang H, Ye N, Zhang J, Wu Q, Sun P, Li L, Zhen X, Zhang A. Liu Z, et al. Among authors: zhang a, zhang j, zhang h. J Med Chem. 2010 Feb 11;53(3):1319-28. doi: 10.1021/jm9015763. J Med Chem. 2010. PMID: 20041669

5

Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.

Fu L, Zhang J, Shen B, Kong L, Liu Y, Tu W, Wang W, Cai X, Wang X, Cheng N, Xia M, Zhou T, Liu Q, Xu Y, Yang J, Gavine P, Philippar U, Attar R, Edwards JP, Venable JD, Dai X. Fu L, et al. Among authors: zhang j. J Med Chem. 2021 Aug 12;64(15):10878-10889. doi: 10.1021/acs.jmedchem.1c00103. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279092

6

Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Zhang J, Zhan P, Wu J, Li Z, Jiang Y, Ge W, Pannecouque C, De Clercq E, Liu X. Zhang J, et al. Bioorg Med Chem. 2011 Jul 15;19(14):4366-76. doi: 10.1016/j.bmc.2011.05.024. Epub 2011 May 23. Bioorg Med Chem. 2011. PMID: 21683601

7

Discovery of indole inhibitors of chemokine receptor 9 (CCR9).

Pandya BA, Baber C, Chan A, Chamberlain B, Chandonnet H, Goss J, Hopper T, Lippa B, Poutsiaka K, Romero J, Stucka S, Varoglu M, Zhang J, Zhang X. Pandya BA, et al. Among authors: zhang j, zhang x. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3322-3325. doi: 10.1016/j.bmcl.2016.05.043. Epub 2016 May 14. Bioorg Med Chem Lett. 2016. PMID: 27256913

8

Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577.

Shi Y, Li C, O'Connor SP, Zhang J, Shi M, Bisaha SN, Wang Y, Sitkoff D, Pudzianowski AT, Huang C, Klei HE, Kish K, Yanchunas J Jr, Liu EC, Hartl KS, Seiler SM, Steinbacher TE, Schumacher WA, Atwal KS, Stein PD. Shi Y, et al. Among authors: zhang j. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. doi: 10.1016/j.bmcl.2009.10.084. Epub 2009 Oct 23. Bioorg Med Chem Lett. 2009. PMID: 19896847

9

Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice.

Li B, Cui W, Liu J, Li R, Liu Q, Xie XH, Ge XL, Zhang J, Song XJ, Wang Y, Guo L. Li B, et al. Among authors: zhang j. Exp Neurol. 2013 Dec;250:239-49. doi: 10.1016/j.expneurol.2013.10.002. Epub 2013 Oct 9. Exp Neurol. 2013. PMID: 24120440

10

Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors.

Shi Y, Sitkoff D, Zhang J, Han W, Hu Z, Stein PD, Wang Y, Kennedy LJ, O'Connor SP, Ahmad S, Liu EC, Seiler SM, Lam PY, Robl JA, Macor JE, Atwal KS, Zahler R. Shi Y, et al. Among authors: zhang j. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5952-8. doi: 10.1016/j.bmcl.2007.07.063. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17855089

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