Zhao YG - Search Results

1

Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors.

Wang Y, Cai W, Zhang G, Yang T, Liu Q, Cheng Y, Zhou L, Ma Y, Cheng Z, Lu S, Zhao YG, Zhang W, Xiang Z, Wang S, Yang L, Wu Q, Orband-Miller LA, Xu Y, Zhang J, Gao R, Huxdorf M, Xiang JN, Zhong Z, Elliott JD, Leung S, Lin X. Wang Y, et al. Among authors: zhao yg. Bioorg Med Chem. 2014 Jan 15;22(2):692-702. doi: 10.1016/j.bmc.2013.12.021. Epub 2013 Dec 21. Bioorg Med Chem. 2014. PMID: 24388993

2

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors.

Wang Y, Cai W, Cheng Y, Yang T, Liu Q, Zhang G, Meng Q, Han F, Huang Y, Zhou L, Xiang Z, Zhao YG, Xu Y, Cheng Z, Lu S, Wu Q, Xiang JN, Elliott JD, Leung S, Ren F, Lin X. Wang Y, et al. Among authors: zhao yg. ACS Med Chem Lett. 2015 May 26;6(7):787-92. doi: 10.1021/acsmedchemlett.5b00122. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191367 Free PMC article.

3

Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor.

Xu H, Zhang H, Luan L, Xu Y, Li C, Wang Y, Han F, Yang T, Ren F, Xiang JN, Elliott JD, Zhao Y, Guo TB, Lu H, Zhang W, Hirst D, Lindon M, Lin X. Xu H, et al. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2456-9. doi: 10.1016/j.bmcl.2012.02.016. Epub 2012 Feb 15. Bioorg Med Chem Lett. 2012. PMID: 22386243

4

Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.

Meng Q, Zhao B, Xu Q, Xu X, Deng G, Li C, Luan L, Ren F, Wang H, Xu H, Xu Y, Zhang H, Xiang JN, Elliott JD, Guo TB, Zhao Y, Zhang W, Lu H, Lin X. Meng Q, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2794-7. doi: 10.1016/j.bmcl.2012.02.083. Epub 2012 Mar 3. Bioorg Med Chem Lett. 2012. PMID: 22429468

5

Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).

Ren F, Deng G, Wang H, Luan L, Meng Q, Xu Q, Xu H, Xu X, Zhang H, Zhao B, Li C, Guo TB, Yang J, Zhang W, Zhao Y, Jia Q, Lu H, Xiang JN, Elliott JD, Lin X. Ren F, et al. J Med Chem. 2012 May 10;55(9):4286-96. doi: 10.1021/jm2016107. Epub 2012 Apr 20. J Med Chem. 2012. PMID: 22500954

6

Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders.

Xu H, Lu H, Xu Z, Luan L, Li C, Xu Y, Dong K, Zhang J, Li X, Li Y, Liu G, Gong S, Zhao YG, Liu A, Zhang Y, Zhang W, Cai X, Xiang JN, Elliott JD, Lin X. Xu H, et al. Among authors: zhao yg. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402. doi: 10.1021/acsmedchemlett.5b00489. eCollection 2016 Apr 14. ACS Med Chem Lett. 2016. PMID: 27096048 Free PMC article.

7

Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer's disease-related animal models despite reported blood-brain barrier disruption.

Cheng Z, Zhang J, Liu H, Li Y, Zhao Y, Yang E. Cheng Z, et al. Drug Metab Dispos. 2010 Aug;38(8):1355-61. doi: 10.1124/dmd.110.033324. Epub 2010 Apr 28. Drug Metab Dispos. 2010. PMID: 20427691

8

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.

Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ. Liu X, et al. Nat Med. 2010 Feb;16(2):191-7. doi: 10.1038/nm.2077. Epub 2010 Jan 10. Nat Med. 2010. Retraction in: Nat Med. 2013 Dec;19(12):1673. doi: 10.1038/nm1213-1673 PMID: 20062065 Retracted.

9

A chemical genomics screen to discover genes that modulate neural stem cell differentiation.

Kim KJ, Wang J, Xu X, Wu S, Zhang W, Qin Z, Wu F, Liu A, Zhao Y, Fang H, Zhu M, Zhao J, Zhong Z. Kim KJ, et al. J Biomol Screen. 2012 Feb;17(2):129-39. doi: 10.1177/1087057111422379. Epub 2011 Sep 23. J Biomol Screen. 2012. PMID: 21948800

10

Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination.

Chen Y, Zhen W, Guo T, Zhao Y, Liu A, Rubio JP, Krull D, Richardson JC, Lu H, Wang R. Chen Y, et al. PLoS One. 2017 Dec 18;12(12):e0189380. doi: 10.1371/journal.pone.0189380. eCollection 2017. PLoS One. 2017. PMID: 29253893 Free PMC article.

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