Ly J - Search Results

1

Investigations into the mechanisms of pyridine ring cleavage in vismodegib.

Khojasteh SC, Yue Q, Ma S, Castanedo G, Chen JZ, Lyssikatos J, Mulder T, Takahashi R, Ly J, Messick K, Jia W, Liu L, Hop CE, Wong H. Khojasteh SC, et al. Among authors: ly j. Drug Metab Dispos. 2014 Mar;42(3):343-51. doi: 10.1124/dmd.113.055715. Epub 2014 Jan 3. Drug Metab Dispos. 2014. PMID: 24389420

2

Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.

Choo EF, Belvin M, Boggs J, Deng Y, Hoeflich KP, Ly J, Merchant M, Orr C, Plise E, Robarge K, Martini JF, Kassees R, Aoyama RG, Ramaiya A, Johnston SH. Choo EF, et al. Among authors: ly j. Drug Metab Dispos. 2012 May;40(5):919-27. doi: 10.1124/dmd.111.043778. Epub 2012 Feb 7. Drug Metab Dispos. 2012. PMID: 22315332

3

Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.

Chang JH, Ly J, Plise E, Zhang X, Messick K, Wright M, Cheong J. Chang JH, et al. Among authors: ly j. Drug Metab Dispos. 2014 Jun;42(6):1067-73. doi: 10.1124/dmd.114.057968. Epub 2014 Mar 26. Drug Metab Dispos. 2014. PMID: 24671957

4

Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS.

Liang X, Yang L, Qin AR, Ly J, Liederer BM, Messick K, Ma S, Zak M, Dragovich PS, Dean BJ, Hop CE, Deng Y. Liang X, et al. Among authors: ly j. Bioanalysis. 2014 Jun;6(11):1445-57. doi: 10.4155/bio.14.8. Bioanalysis. 2014. PMID: 25046046

5

Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib.

Choo EF, Ly J, Chan J, Shahidi-Latham SK, Messick K, Plise E, Quiason CM, Yang L. Choo EF, et al. Among authors: ly j. Mol Pharm. 2014 Nov 3;11(11):4199-207. doi: 10.1021/mp500435s. Epub 2014 Oct 3. Mol Pharm. 2014. PMID: 25243894

6

Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor.

Choo EF, Woolsey S, DeMent K, Ly J, Messick K, Qin A, Takahashi R. Choo EF, et al. Among authors: ly j. Drug Metab Dispos. 2015 Jun;43(6):864-9. doi: 10.1124/dmd.115.063743. Epub 2015 Mar 26. Drug Metab Dispos. 2015. PMID: 25813936

7

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors.

Hu H, Wang X, Chan GK, Chang JH, Do S, Drummond J, Ebens A, Lee W, Ly J, Lyssikatos JP, Murray J, Moffat JG, Chao Q, Tsui V, Wallweber H, Kolesnikov A. Hu H, et al. Among authors: ly j. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5258-64. doi: 10.1016/j.bmcl.2015.09.052. Epub 2015 Sep 30. Bioorg Med Chem Lett. 2015. PMID: 26459208

8

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats.

Parrish KE, Mao J, Chen J, Jaochico A, Ly J, Ho Q, Mukadam S, Wright M. Parrish KE, et al. Among authors: ly j. Biopharm Drug Dispos. 2016 May;37(4):200-11. doi: 10.1002/bdd.2000. Biopharm Drug Dispos. 2016. PMID: 26637499

9

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.

Takahashi RH, Ma S, Yue Q, Kim-Kang H, Yi Y, Ly J, Boggs JW, Fettes A, McClory A, Deng Y, Hop CE, Khojasteh SC, Choo EF. Takahashi RH, et al. Among authors: ly j. Xenobiotica. 2017 Jan;47(1):50-65. doi: 10.3109/00498254.2016.1157645. Epub 2016 Apr 8. Xenobiotica. 2017. PMID: 27055783

10

Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model.

Chang JH, Chen J, Liu L, Messick K, Ly J. Chang JH, et al. Among authors: ly j. Drug Metab Dispos. 2016 Nov;44(11):1736-1741. doi: 10.1124/dmd.116.072132. Epub 2016 Aug 18. Drug Metab Dispos. 2016. PMID: 27538915

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