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Dopamine neuron dysfunction and loss in the PrknR275W mouse model of juvenile parkinsonism.
Regoni M, Zanetti L, Sevegnani M, Domenicale C, Magnabosco S, Patel JC, Fernandes MK, Feeley RM, Monzani E, Mini C, Comai S, Cherchi L, De Gregorio D, Soliman I, Ruto F, Croci L, Consalez G, Rodighiero S, Ciammola A, Valtorta F, Morari M, Piccoli G, Rice ME, Sassone J. Regoni M, et al. Among authors: comai s. Brain. 2024 Oct 1:awae276. doi: 10.1093/brain/awae276. Online ahead of print. Brain. 2024. PMID: 39350737
The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.
Shram MJ, Henningfield JE, Apseloff G, Gorodetzky CW, De Martin S, Vocci FL, Sapienza FL, Kosten TR, Huston J, Buchhalter A, Ashworth J, Lanier R, Folli F, Mattarei A, Guidetti C, Comai S, O'Gorman C, Traversa S, Inturrisi CE, Manfredi PL, Pappagallo M. Shram MJ, et al. Among authors: comai s. Transl Psychiatry. 2023 Jun 7;13(1):192. doi: 10.1038/s41398-023-02473-8. Transl Psychiatry. 2023. PMID: 37286536 Free PMC article. Clinical Trial.
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand.
Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G, Rivara S, Bedini A, Angeloni D, Fraschini F, Mor M, Tarzia G, Descarries L, Gobbi G. Ochoa-Sanchez R, et al. Among authors: comai s. J Neurosci. 2011 Dec 14;31(50):18439-52. doi: 10.1523/JNEUROSCI.2676-11.2011. J Neurosci. 2011. PMID: 22171046 Free PMC article.
115 results