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Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.
Dewhurst SM, McGranahan N, Burrell RA, Rowan AJ, Grönroos E, Endesfelder D, Joshi T, Mouradov D, Gibbs P, Ward RL, Hawkins NJ, Szallasi Z, Sieber OM, Swanton C. Dewhurst SM, et al. Among authors: burrell ra. Cancer Discov. 2014 Feb;4(2):175-185. doi: 10.1158/2159-8290.CD-13-0285. Epub 2014 Jan 19. Cancer Discov. 2014. PMID: 24436049 Free PMC article.
Replication stress links structural and numerical cancer chromosomal instability.
Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C. Burrell RA, et al. Nature. 2013 Feb 28;494(7438):492-496. doi: 10.1038/nature11935. Nature. 2013. PMID: 23446422 Free PMC article.
The evolution of the unstable cancer genome.
Burrell RA, Swanton C. Burrell RA, et al. Curr Opin Genet Dev. 2014 Feb;24:61-7. doi: 10.1016/j.gde.2013.11.011. Epub 2013 Dec 31. Curr Opin Genet Dev. 2014. PMID: 24657538 Review.
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.
Kanu N, Grönroos E, Martinez P, Burrell RA, Yi Goh X, Bartkova J, Maya-Mendoza A, Mistrík M, Rowan AJ, Patel H, Rabinowitz A, East P, Wilson G, Santos CR, McGranahan N, Gulati S, Gerlinger M, Birkbak NJ, Joshi T, Alexandrov LB, Stratton MR, Powles T, Matthews N, Bates PA, Stewart A, Szallasi Z, Larkin J, Bartek J, Swanton C. Kanu N, et al. Among authors: burrell ra. Oncogene. 2015 Nov 12;34(46):5699-708. doi: 10.1038/onc.2015.24. Epub 2015 Mar 2. Oncogene. 2015. PMID: 25728682 Free PMC article.
BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.
López-García C, Sansregret L, Domingo E, McGranahan N, Hobor S, Birkbak NJ, Horswell S, Grönroos E, Favero F, Rowan AJ, Matthews N, Begum S, Phillimore B, Burrell R, Oukrif D, Spencer-Dene B, Kovac M, Stamp G, Stewart A, Danielsen H, Novelli M, Tomlinson I, Swanton C. López-García C, et al. Cancer Cell. 2017 Jan 9;31(1):79-93. doi: 10.1016/j.ccell.2016.11.001. Cancer Cell. 2017. PMID: 28073006 Free PMC article.
34 results