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Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.
Kalyanasundaram A, Viatchenko-Karpinski S, Belevych AE, Lacombe VA, Hwang HS, Knollmann BC, Gyorke S, Periasamy M. Kalyanasundaram A, et al. Among authors: knollmann bc. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H253-61. doi: 10.1152/ajpheart.00578.2011. Epub 2011 Oct 7. Am J Physiol Heart Circ Physiol. 2012. PMID: 21984545 Free PMC article.
We recently reported that the mutant CASQ2(D307H) protein can be stably expressed in CASQ2 null hearts, and it targets appropriately to the junctional SR (Kalyanasundaram A, Bal NC, Franzini-Armstrong C, Knollmann BC, Periasamy M. J Biol Chem 285: 3076-3083, 2010). …
We recently reported that the mutant CASQ2(D307H) protein can be stably expressed in CASQ2 null hearts, and it targets appropriately to the …
Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.
Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV. Glukhov AV, et al. Among authors: knollmann bc. Eur Heart J. 2015 Mar 14;36(11):686-97. doi: 10.1093/eurheartj/eht452. Epub 2013 Nov 11. Eur Heart J. 2015. PMID: 24216388 Free PMC article.
Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.
Liu B, Walton SD, Ho HT, Belevych AE, Tikunova SB, Bonilla I, Shettigar V, Knollmann BC, Priori SG, Volpe P, Radwański PB, Davis JP, Györke S. Liu B, et al. Among authors: knollmann bc. J Am Heart Assoc. 2018 May 2;7(10):e008155. doi: 10.1161/JAHA.117.008155. J Am Heart Assoc. 2018. PMID: 29720499 Free PMC article.
Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS.
Hamilton S, Terentyeva R, Martin B, Perger F, Li J, Stepanov A, Bonilla IM, Knollmann BC, Radwański PB, Györke S, Belevych AE, Terentyev D. Hamilton S, et al. Among authors: knollmann bc. Basic Res Cardiol. 2020 May 22;115(4):38. doi: 10.1007/s00395-020-0797-z. Basic Res Cardiol. 2020. PMID: 32444920 Free PMC article.
186 results