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The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases.
Odagiri H, Kadomatsu T, Endo M, Masuda T, Morioka MS, Fukuhara S, Miyamoto T, Kobayashi E, Miyata K, Aoi J, Horiguchi H, Nishimura N, Terada K, Yakushiji T, Manabe I, Mochizuki N, Mizuta H, Oike Y. Odagiri H, et al. Among authors: masuda t. Sci Signal. 2014 Jan 21;7(309):ra7. doi: 10.1126/scisignal.2004612. Sci Signal. 2014. PMID: 24448647
Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.
Endo M, Nakano M, Kadomatsu T, Fukuhara S, Kuroda H, Mikami S, Hato T, Aoi J, Horiguchi H, Miyata K, Odagiri H, Masuda T, Harada M, Horio H, Hishima T, Nomori H, Ito T, Yamamoto Y, Minami T, Okada S, Takahashi T, Mochizuki N, Iwase H, Oike Y. Endo M, et al. Among authors: masuda t. Cancer Res. 2012 Apr 1;72(7):1784-94. doi: 10.1158/0008-5472.CAN-11-3878. Epub 2012 Feb 16. Cancer Res. 2012. PMID: 22345152
Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.
Nakamura T, Okada T, Endo M, Kadomatsu T, Taniwaki T, Sei A, Odagiri H, Masuda T, Fujimoto T, Nakamura T, Oike Y, Mizuta H. Nakamura T, et al. Among authors: masuda t. PLoS One. 2014 Jan 17;9(1):e85542. doi: 10.1371/journal.pone.0085542. eCollection 2014. PLoS One. 2014. PMID: 24465594 Free PMC article.
Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling.
Horiguchi H, Endo M, Miyamoto Y, Sakamoto Y, Odagiri H, Masuda T, Kadomatsu T, Tanoue H, Motokawa I, Terada K, Morioka MS, Manabe I, Baba H, Oike Y. Horiguchi H, et al. Among authors: masuda t. Cancer Sci. 2014 Dec;105(12):1550-9. doi: 10.1111/cas.12554. Epub 2014 Nov 5. Cancer Sci. 2014. PMID: 25287946 Free PMC article.
Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.
Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y. Yugami M, et al. Among authors: masuda t. J Biol Chem. 2016 Sep 2;291(36):18843-52. doi: 10.1074/jbc.M116.720870. Epub 2016 Jul 11. J Biol Chem. 2016. PMID: 27402837 Free PMC article.
Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y. Tanoue H, et al. Among authors: masuda t. Osteoarthritis Cartilage. 2018 Jan;26(1):108-117. doi: 10.1016/j.joca.2017.10.011. Epub 2017 Oct 23. Osteoarthritis Cartilage. 2018. PMID: 29074299 Free article.
3,375 results