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The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases.
Odagiri H, Kadomatsu T, Endo M, Masuda T, Morioka MS, Fukuhara S, Miyamoto T, Kobayashi E, Miyata K, Aoi J, Horiguchi H, Nishimura N, Terada K, Yakushiji T, Manabe I, Mochizuki N, Mizuta H, Oike Y. Odagiri H, et al. Among authors: mizuta h. Sci Signal. 2014 Jan 21;7(309):ra7. doi: 10.1126/scisignal.2004612. Sci Signal. 2014. PMID: 24448647
ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling.
Masuda T, Endo M, Yamamoto Y, Odagiri H, Kadomatsu T, Nakamura T, Tanoue H, Ito H, Yugami M, Miyata K, Morinaga J, Horiguchi H, Motokawa I, Terada K, Morioka MS, Manabe I, Iwase H, Mizuta H, Oike Y. Masuda T, et al. Among authors: mizuta h. Sci Rep. 2015 Mar 16;5:9170. doi: 10.1038/srep09170. Sci Rep. 2015. PMID: 25773070 Free PMC article.
Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.
Nakamura T, Okada T, Endo M, Kadomatsu T, Taniwaki T, Sei A, Odagiri H, Masuda T, Fujimoto T, Nakamura T, Oike Y, Mizuta H. Nakamura T, et al. Among authors: mizuta h. PLoS One. 2014 Jan 17;9(1):e85542. doi: 10.1371/journal.pone.0085542. eCollection 2014. PLoS One. 2014. PMID: 24465594 Free PMC article.
Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.
Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y. Yugami M, et al. Among authors: mizuta h. J Biol Chem. 2016 Sep 2;291(36):18843-52. doi: 10.1074/jbc.M116.720870. Epub 2016 Jul 11. J Biol Chem. 2016. PMID: 27402837 Free PMC article.
Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y. Tanoue H, et al. Among authors: mizuta h. Osteoarthritis Cartilage. 2018 Jan;26(1):108-117. doi: 10.1016/j.joca.2017.10.011. Epub 2017 Oct 23. Osteoarthritis Cartilage. 2018. PMID: 29074299 Free article.
The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.
Tsukano H, Gotoh T, Endo M, Miyata K, Tazume H, Kadomatsu T, Yano M, Iwawaki T, Kohno K, Araki K, Mizuta H, Oike Y. Tsukano H, et al. Among authors: mizuta h. Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1925-32. doi: 10.1161/ATVBAHA.110.206094. Epub 2010 Jul 22. Arterioscler Thromb Vasc Biol. 2010. PMID: 20651282
354 results