Clem A - Search Results

1

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism.

Klarer AC, O'Neal J, Imbert-Fernandez Y, Clem A, Ellis SR, Clark J, Clem B, Chesney J, Telang S. Klarer AC, et al. Among authors: clem a. Cancer Metab. 2014 Jan 23;2(1):2. doi: 10.1186/2049-3002-2-2. Cancer Metab. 2014. PMID: 24451478 Free PMC article.

2

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.

Telang S, Clem BF, Klarer AC, Clem AL, Trent JO, Bucala R, Chesney J. Telang S, et al. J Transl Med. 2012 May 16;10:95. doi: 10.1186/1479-5876-10-95. J Transl Med. 2012. PMID: 22591674 Free PMC article.

3

Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer.

Clem BF, O'Neal J, Tapolsky G, Clem AL, Imbert-Fernandez Y, Kerr DA 2nd, Klarer AC, Redman R, Miller DM, Trent JO, Telang S, Chesney J. Clem BF, et al. Among authors: clem al. Mol Cancer Ther. 2013 Aug;12(8):1461-70. doi: 10.1158/1535-7163.MCT-13-0097. Epub 2013 May 14. Mol Cancer Ther. 2013. PMID: 23674815 Free PMC article.

4

Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3).

Imbert-Fernandez Y, Clem BF, O'Neal J, Kerr DA, Spaulding R, Lanceta L, Clem AL, Telang S, Chesney J. Imbert-Fernandez Y, et al. Among authors: clem al. J Biol Chem. 2014 Mar 28;289(13):9440-8. doi: 10.1074/jbc.M113.529990. Epub 2014 Feb 10. J Biol Chem. 2014. PMID: 24515104 Free PMC article.

5

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27.

Yalcin A, Clem BF, Imbert-Fernandez Y, Ozcan SC, Peker S, O'Neal J, Klarer AC, Clem AL, Telang S, Chesney J. Yalcin A, et al. Among authors: clem al. Cell Death Dis. 2014 Jul 17;5(7):e1337. doi: 10.1038/cddis.2014.292. Cell Death Dis. 2014. PMID: 25032860 Free PMC article.

6

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.

Clem B, Telang S, Clem A, Yalcin A, Meier J, Simmons A, Rasku MA, Arumugam S, Dean WL, Eaton J, Lane A, Trent JO, Chesney J. Clem B, et al. Among authors: clem a. Mol Cancer Ther. 2008 Jan;7(1):110-20. doi: 10.1158/1535-7163.MCT-07-0482. Mol Cancer Ther. 2008. PMID: 18202014

7

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer.

O'Neal J, Clem A, Reynolds L, Dougherty S, Imbert-Fernandez Y, Telang S, Chesney J, Clem BF. O'Neal J, et al. Among authors: clem a. Breast Cancer Res Treat. 2016 Nov;160(1):29-40. doi: 10.1007/s10549-016-3968-8. Epub 2016 Sep 9. Breast Cancer Res Treat. 2016. PMID: 27613609

8

Depletion of ascorbic acid restricts angiogenesis and retards tumor growth in a mouse model.

Telang S, Clem AL, Eaton JW, Chesney J. Telang S, et al. Neoplasia. 2007 Jan;9(1):47-56. doi: 10.1593/neo.06664. Neoplasia. 2007. PMID: 17325743 Free PMC article.

9

Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.

Yalcin A, Clem BF, Simmons A, Lane A, Nelson K, Clem AL, Brock E, Siow D, Wattenberg B, Telang S, Chesney J. Yalcin A, et al. Among authors: clem bf, clem al. J Biol Chem. 2009 Sep 4;284(36):24223-32. doi: 10.1074/jbc.M109.016816. Epub 2009 May 27. J Biol Chem. 2009. PMID: 19473963 Free PMC article.

10

Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma.

Telang S, Rasku MA, Clem AL, Carter K, Klarer AC, Badger WR, Milam RA, Rai SN, Pan J, Gragg H, Clem BF, McMasters KM, Miller DM, Chesney J. Telang S, et al. Among authors: clem bf, clem al. BMC Cancer. 2011 Dec 13;11:515. doi: 10.1186/1471-2407-11-515. BMC Cancer. 2011. PMID: 22165955 Free PMC article. Clinical Trial.

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