Lum BL - Search Results

1

The effect of rifampicin, a prototypical CYP3A4 inducer, on erlotinib pharmacokinetics in healthy subjects.

Hamilton M, Wolf JL, Drolet DW, Fettner SH, Rakhit AK, Witt K, Lum BL. Hamilton M, et al. Among authors: lum bl. Cancer Chemother Pharmacol. 2014 Mar;73(3):613-21. doi: 10.1007/s00280-014-2390-3. Epub 2014 Jan 29. Cancer Chemother Pharmacol. 2014. PMID: 24474302 Clinical Trial.

2

The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. Rakhit A, et al. Among authors: lum bl. Eur J Clin Pharmacol. 2008 Jan;64(1):31-41. doi: 10.1007/s00228-007-0396-z. Epub 2007 Nov 14. Eur J Clin Pharmacol. 2008. PMID: 18000659 Clinical Trial.

3

Effect of erlotinib on CYP3A activity, evaluated in vitro and by dual probes in patients with cancer.

Calvert H, Twelves C, Ranson M, Plummer R, Fettner S, Pantze M, Ling J, Hamilton M, Lum BL, Rakhit A. Calvert H, et al. Among authors: lum bl. Anticancer Drugs. 2014 Aug;25(7):832-40. doi: 10.1097/CAD.0000000000000099. Anticancer Drugs. 2014. PMID: 24637575 Clinical Trial.

4

Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized, crossover study in healthy subjects.

Frohna P, Lu J, Eppler S, Hamilton M, Wolf J, Rakhit A, Ling J, Kenkare-Mitra SR, Lum BL. Frohna P, et al. Among authors: lum bl. J Clin Pharmacol. 2006 Mar;46(3):282-90. doi: 10.1177/0091270005284193. J Clin Pharmacol. 2006. PMID: 16490804 Clinical Trial.

5

Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non-small cell lung cancer.

Lu JF, Eppler SM, Wolf J, Hamilton M, Rakhit A, Bruno R, Lum BL. Lu JF, et al. Among authors: lum bl. Clin Pharmacol Ther. 2006 Aug;80(2):136-45. doi: 10.1016/j.clpt.2006.04.007. Clin Pharmacol Ther. 2006. PMID: 16890575 Clinical Trial.

6

Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals.

Ling J, Fettner S, Lum BL, Riek M, Rakhit A. Ling J, et al. Among authors: lum bl. Anticancer Drugs. 2008 Feb;19(2):209-16. doi: 10.1097/CAD.0b013e3282f2d8e4. Anticancer Drugs. 2008. PMID: 18176118 Clinical Trial.

7

Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: omeprazole and ranitidine.

Kletzl H, Giraudon M, Ducray PS, Abt M, Hamilton M, Lum BL. Kletzl H, et al. Among authors: lum bl. Anticancer Drugs. 2015 Jun;26(5):565-72. doi: 10.1097/CAD.0000000000000212. Anticancer Drugs. 2015. PMID: 25643050 Clinical Trial.

8

Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers.

Ling J, Johnson KA, Miao Z, Rakhit A, Pantze MP, Hamilton M, Lum BL, Prakash C. Ling J, et al. Among authors: lum bl. Drug Metab Dispos. 2006 Mar;34(3):420-6. doi: 10.1124/dmd.105.007765. Epub 2005 Dec 28. Drug Metab Dispos. 2006. PMID: 16381666

9

Comparative pharmacokinetics of subcutaneous trastuzumab administered via handheld syringe or proprietary single-use injection device in healthy males.

Wynne CJ, Ellis-Pegler RB, Waaka DS, Schwabe C, Lehle M, Heinzmann D, Mangat R, Li C, Dick AE, Cranshaw NA, Lum BL. Wynne CJ, et al. Among authors: lum bl. Cancer Chemother Pharmacol. 2013 Nov;72(5):1079-87. doi: 10.1007/s00280-013-2273-z. Epub 2013 Sep 22. Cancer Chemother Pharmacol. 2013. PMID: 24057039 Clinical Trial.

10

Clinical pharmacokinetics of bevacizumab in patients with solid tumors.

Lu JF, Bruno R, Eppler S, Novotny W, Lum B, Gaudreault J. Lu JF, et al. Cancer Chemother Pharmacol. 2008 Oct;62(5):779-86. doi: 10.1007/s00280-007-0664-8. Epub 2008 Jan 19. Cancer Chemother Pharmacol. 2008. PMID: 18205003

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