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Page 1
Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.
Forbes B, O'Lone R, Allen PP, Cahn A, Clarke C, Collinge M, Dailey LA, Donnelly LE, Dybowski J, Hassall D, Hildebrand D, Jones R, Kilgour J, Klapwijk J, Maier CC, McGovern T, Nikula K, Parry JD, Reed MD, Robinson I, Tomlinson L, Wolfreys A. Forbes B, et al. Among authors: parry jd. Adv Drug Deliv Rev. 2014 May;71:15-33. doi: 10.1016/j.addr.2014.02.001. Epub 2014 Feb 13. Adv Drug Deliv Rev. 2014. PMID: 24530633 Free article.
Clinical expert panel on monitoring potential lung toxicity of inhaled oligonucleotides: consensus points and recommendations.
Alton EW, Boushey HA, Garn H, Green FH, Hodges M, Martin RJ, Murdoch RD, Renz H, Shrewsbury SB, Seguin R, Johnson G, Parry JD, Tepper J, Renzi P, Cavagnaro J, Ferrari N. Alton EW, et al. Among authors: parry jd. Nucleic Acid Ther. 2012 Aug;22(4):246-54. doi: 10.1089/nat.2012.0345. Epub 2012 Jul 18. Nucleic Acid Ther. 2012. PMID: 22809313 Free PMC article.
Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Therapeutic Oligonucleotide Safety Assessment.
Tessier Y, Achanzar W, Mihalcik L, Amuzie C, Andersson P, Parry JD, Moggs J, Whiteley LO. Tessier Y, et al. Among authors: parry jd. Nucleic Acid Ther. 2021 Feb;31(1):7-20. doi: 10.1089/nat.2020.0892. Epub 2020 Oct 15. Nucleic Acid Ther. 2021. PMID: 33054599
Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.
Kamola PJ, Maratou K, Wilson PA, Rush K, Mullaney T, McKevitt T, Evans P, Ridings J, Chowdhury P, Roulois A, Fairchild A, McCawley S, Cartwright K, Gooderham NJ, Gant TW, Moores K, Hughes SA, Edbrooke MR, Clark K, Parry JD. Kamola PJ, et al. Among authors: parry jd. Mol Ther Nucleic Acids. 2017 Sep 15;8:383-394. doi: 10.1016/j.omtn.2017.07.003. Epub 2017 Jul 8. Mol Ther Nucleic Acids. 2017. PMID: 28918038 Free PMC article.
In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.
Kamola PJ, Kitson JD, Turner G, Maratou K, Eriksson S, Panjwani A, Warnock LC, Douillard Guilloux GA, Moores K, Koppe EL, Wixted WE, Wilson PA, Gooderham NJ, Gant TW, Clark KL, Hughes SA, Edbrooke MR, Parry JD. Kamola PJ, et al. Among authors: parry jd. Nucleic Acids Res. 2015 Oct 15;43(18):8638-50. doi: 10.1093/nar/gkv857. Epub 2015 Sep 3. Nucleic Acids Res. 2015. PMID: 26338776 Free PMC article.
Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.
Parry JD, Pointon AV, Lutz U, Teichert F, Charlwood JK, Chan PH, Athersuch TJ, Taylor EL, Singh R, Luo J, Phillips KM, Vetillard A, Lyon JJ, Keun HC, Lutz WK, Gant TW. Parry JD, et al. Chem Res Toxicol. 2009 Apr;22(4):717-25. doi: 10.1021/tx800472z. Chem Res Toxicol. 2009. PMID: 19338340
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