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Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.
Cook JR, Carta L, Bénard L, Chemaly ER, Chiu E, Rao SK, Hampton TG, Yurchenco P; GenTAC Registry Consortium; Costa KD, Hajjar RJ, Ramirez F. Cook JR, et al. Among authors: carta l. J Clin Invest. 2014 Mar;124(3):1329-39. doi: 10.1172/JCI71059. Epub 2014 Feb 17. J Clin Invest. 2014. PMID: 24531548 Free PMC article.
Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.
Cook JR, Clayton NP, Carta L, Galatioto J, Chiu E, Smaldone S, Nelson CA, Cheng SH, Wentworth BM, Ramirez F. Cook JR, et al. Among authors: carta l. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):911-7. doi: 10.1161/ATVBAHA.114.305150. Epub 2015 Jan 22. Arterioscler Thromb Vasc Biol. 2015. PMID: 25614286 Free PMC article.
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC. Habashi JP, et al. Among authors: carta l. Science. 2006 Apr 7;312(5770):117-21. doi: 10.1126/science.1124287. Science. 2006. PMID: 16601194 Free PMC article.
74 results