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The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.
Dittmann A, Werner T, Chung CW, Savitski MM, Fälth Savitski M, Grandi P, Hopf C, Lindon M, Neubauer G, Prinjha RK, Bantscheff M, Drewes G. Dittmann A, et al. Among authors: falth savitski m. ACS Chem Biol. 2014 Feb 21;9(2):495-502. doi: 10.1021/cb400789e. Epub 2013 Dec 10. ACS Chem Biol. 2014. PMID: 24533473
Biological plasticity rescues target activity in CRISPR knock outs.
Smits AH, Ziebell F, Joberty G, Zinn N, Mueller WF, Clauder-Münster S, Eberhard D, Fälth Savitski M, Grandi P, Jakob P, Michon AM, Sun H, Tessmer K, Bürckstümmer T, Bantscheff M, Steinmetz LM, Drewes G, Huber W. Smits AH, et al. Among authors: falth savitski m. Nat Methods. 2019 Nov;16(11):1087-1093. doi: 10.1038/s41592-019-0614-5. Epub 2019 Oct 28. Nat Methods. 2019. PMID: 31659326
Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition.
Burtscher ML, Gade S, Garrido-Rodriguez M, Rutkowska A, Werner T, Eberl HC, Petretich M, Knopf N, Zirngibl K, Grandi P, Bergamini G, Bantscheff M, Fälth-Savitski M, Saez-Rodriguez J. Burtscher ML, et al. Among authors: falth savitski m. Mol Syst Biol. 2024 Apr;20(4):458-474. doi: 10.1038/s44320-024-00025-w. Epub 2024 Mar 7. Mol Syst Biol. 2024. PMID: 38454145 Free PMC article.