Hop CE - Search Results

1

1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9.

Sodhi JK, Ford KA, Mukadam S, Wong S, Hop CE, Khojasteh SC, Halladay JS. Sodhi JK, et al. Among authors: hop ce. Drug Metab Dispos. 2014 May;42(5):813-7. doi: 10.1124/dmd.113.055913. Epub 2014 Feb 18. Drug Metab Dispos. 2014. PMID: 24550229

2

Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.

Balani SK, Xu X, Arison BH, Silva MV, Gries A, DeLuna FA, Cui D, Kari PH, Ly T, Hop CE, Singh R, Wallace MA, Dean DC, Lin JH, Pearson PG, Baillie TA. Balani SK, et al. Among authors: hop ce. Drug Metab Dispos. 2000 Nov;28(11):1274-8. Drug Metab Dispos. 2000. PMID: 11038152

3

A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

Yin W, Doss GA, Stearns RA, Chaudhary AG, Hop CE, Franklin RB, Kumar S. Yin W, et al. Among authors: hop ce. Drug Metab Dispos. 2003 Feb;31(2):215-23. doi: 10.1124/dmd.31.2.215. Drug Metab Dispos. 2003. PMID: 12527703

4

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

Huskey SE, Dean BJ, Doss GA, Wang Z, Hop CE, Anari R, Finke PE, Robichaud AJ, Zhang M, Wang B, Strauss JR, Cunningham PK, Feeney WP, Franklin RB, Baillie TA, Chiu SH. Huskey SE, et al. Among authors: hop ce. Drug Metab Dispos. 2004 Feb;32(2):246-58. doi: 10.1124/dmd.32.2.246. Drug Metab Dispos. 2004. PMID: 14744948

5

In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry.

Liu DQ, Karanam BV, Doss GA, Sidler RR, Vincent SH, Hop CE. Liu DQ, et al. Among authors: hop ce. Drug Metab Dispos. 2004 Sep;32(9):1023-31. doi: 10.1124/dmd.104.000059. Drug Metab Dispos. 2004. PMID: 15319345

6

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4.

Kalgutkar AS, Vaz AD, Lame ME, Henne KR, Soglia J, Zhao SX, Abramov YA, Lombardo F, Collin C, Hendsch ZS, Hop CE. Kalgutkar AS, et al. Among authors: hop ce. Drug Metab Dispos. 2005 Feb;33(2):243-53. doi: 10.1124/dmd.104.001735. Epub 2004 Nov 2. Drug Metab Dispos. 2005. PMID: 15523046

7

Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.

Yu LJ, Chen Y, Deninno MP, O'Connell TN, Hop CE. Yu LJ, et al. Among authors: hop ce. Drug Metab Dispos. 2005 Apr;33(4):484-8. doi: 10.1124/dmd.104.002840. Epub 2005 Jan 7. Drug Metab Dispos. 2005. PMID: 15640374

8

On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay.

Berezhkovskiy LM, Khojasteh SC, Halladay JS, Hop CE. Berezhkovskiy LM, et al. Among authors: hop ce. J Pharm Sci. 2009 Jun;98(6):1922-7. doi: 10.1002/jps.21582. J Pharm Sci. 2009. PMID: 18837013

9

Inhibitory properties of trapping agents: glutathione, potassium cyanide, and methoxylamine, against major human cytochrome p450 isoforms.

Zhang C, Wong S, Delarosa EM, Kenny JR, Halladay JS, Hop CE, Khojasteh-Bakht SC. Zhang C, et al. Among authors: hop ce. Drug Metab Lett. 2009 Apr;3(2):125-9. doi: 10.2174/187231209788654126. Drug Metab Lett. 2009. PMID: 19601875

10

Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.

Wong H, Theil FP, Cui Y, Marsters JC Jr, Khojasteh SC, Vernillet L, La H, Song X, Wang H, Morinello EJ, Deng Y, Hop CE. Wong H, et al. Among authors: hop ce. Drug Metab Dispos. 2010 Jul;38(7):1029-38. doi: 10.1124/dmd.110.032680. Epub 2010 Apr 20. Drug Metab Dispos. 2010. PMID: 20406853

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