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The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.
Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. Soliman MA, et al. Among authors: dennis jw. Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Sci Signal. 2014. PMID: 24550542 Free PMC article.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K. So J, et al. Among authors: dennis jw. Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700. Sci Signal. 2015. PMID: 25852190
Temporal regulation of EGF signalling networks by the scaffold protein Shc1.
Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T. Zheng Y, et al. Among authors: dennis jw. Nature. 2013 Jul 11;499(7457):166-71. doi: 10.1038/nature12308. Nature. 2013. PMID: 23846654 Free PMC article.
226 results