Le TM - Search Results

1

Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.

Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. Nathanson DA, et al. Among authors: le tm. J Exp Med. 2014 Mar 10;211(3):473-86. doi: 10.1084/jem.20131738. Epub 2014 Feb 24. J Exp Med. 2014. PMID: 24567448 Free PMC article.

2

A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples.

Le T, Kim KP, Fan G, Faull KF. Le T, et al. Anal Biochem. 2011 May 15;412(2):203-9. doi: 10.1016/j.ab.2011.01.026. Epub 2011 Jan 24. Anal Biochem. 2011. PMID: 21272560 Free PMC article.

3

Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.

Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. Vincent JJ, et al. Cell Stem Cell. 2013 Apr 4;12(4):470-8. doi: 10.1016/j.stem.2013.01.016. Epub 2013 Feb 14. Cell Stem Cell. 2013. PMID: 23415914 Free PMC article.

4

Tet1 is critical for neuronal activity-regulated gene expression and memory extinction.

Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, Faull KF, Jaenisch R, Tsai LH. Rudenko A, et al. Neuron. 2013 Sep 18;79(6):1109-1122. doi: 10.1016/j.neuron.2013.08.003. Neuron. 2013. PMID: 24050401 Free PMC article.

5

Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.

Dawlaty MM, Breiling A, Le T, Barrasa MI, Raddatz G, Gao Q, Powell BE, Cheng AW, Faull KF, Lyko F, Jaenisch R. Dawlaty MM, et al. Dev Cell. 2014 Apr 14;29(1):102-11. doi: 10.1016/j.devcel.2014.03.003. Dev Cell. 2014. PMID: 24735881 Free PMC article.

6

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.

Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, Li W, Goodell MA. Sun D, et al. Cell Stem Cell. 2014 May 1;14(5):673-88. doi: 10.1016/j.stem.2014.03.002. Cell Stem Cell. 2014. PMID: 24792119 Free PMC article.

7

Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells.

Huang K, Wu Z, Liu Z, Hu G, Yu J, Chang KH, Kim KP, Le T, Faull KF, Rao N, Gennery A, Xue Z, Wang CY, Pellegrini M, Fan G. Huang K, et al. Hum Mol Genet. 2014 Dec 15;23(24):6448-57. doi: 10.1093/hmg/ddu365. Epub 2014 Jul 15. Hum Mol Genet. 2014. PMID: 25027325 Free PMC article.

8

Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.

Calkins KL, Sanchez LA, Tseng CH, Faull KF, Yoon AJ, Ryan CM, Le T, Shew SB. Calkins KL, et al. JPEN J Parenter Enteral Nutr. 2016 Feb;40(2):226-34. doi: 10.1177/0148607114546375. Epub 2014 Aug 19. JPEN J Parenter Enteral Nutr. 2016. PMID: 25139979 Free PMC article. Clinical Trial.

9

Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.

Nomme J, Li Z, Gipson RM, Wang J, Armijo AL, Le T, Poddar S, Smith T, Santarsiero BD, Nguyen HA, Czernin J, Alexandrova AN, Jung ME, Radu CG, Lavie A. Nomme J, et al. J Med Chem. 2014 Nov 26;57(22):9480-94. doi: 10.1021/jm501124j. Epub 2014 Nov 7. J Med Chem. 2014. PMID: 25341194 Free PMC article.

10

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.

Kollareddy M, Dimitrova E, Vallabhaneni KC, Chan A, Le T, Chauhan KM, Carrero ZI, Ramakrishnan G, Watabe K, Haupt Y, Haupt S, Pochampally R, Boss GR, Romero DG, Radu CG, Martinez LA. Kollareddy M, et al. Nat Commun. 2015 Jun 12;6:7389. doi: 10.1038/ncomms8389. Nat Commun. 2015. PMID: 26067754 Free PMC article.

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