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A phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses.
Markert JM, Razdan SN, Kuo HC, Cantor A, Knoll A, Karrasch M, Nabors LB, Markiewicz M, Agee BS, Coleman JM, Lakeman AD, Palmer CA, Parker JN, Whitley RJ, Weichselbaum RR, Fiveash JB, Gillespie GY. Markert JM, et al. Among authors: whitley rj. Mol Ther. 2014 May;22(5):1048-55. doi: 10.1038/mt.2014.22. Epub 2014 Feb 27. Mol Ther. 2014. PMID: 24572293 Free PMC article. Clinical Trial.
Evaluation of the safety and biodistribution of M032, an attenuated herpes simplex virus type 1 expressing hIL-12, after intracerebral administration to aotus nonhuman primates.
Roth JC, Cassady KA, Cody JJ, Parker JN, Price KH, Coleman JM, Peggins JO, Noker PE, Powers NW, Grimes SD, Carroll SL, Gillespie GY, Whitley RJ, Markert JM. Roth JC, et al. Among authors: whitley rj. Hum Gene Ther Clin Dev. 2014 Mar;25(1):16-27. doi: 10.1089/humc.2013.201. Hum Gene Ther Clin Dev. 2014. PMID: 24649838 Free PMC article.
Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice.
Bernstock JD, Vicario N, Li R, Nan L, Totsch SK, Schlappi C, Gessler F, Han X, Parenti R, Beierle EA, Whitley RJ, Aban I, Gillespie GY, Markert JM, Friedman GK. Bernstock JD, et al. Among authors: whitley rj. Cancer Gene Ther. 2020 Apr;27(3-4):246-255. doi: 10.1038/s41417-019-0091-0. Epub 2019 Mar 28. Cancer Gene Ther. 2020. PMID: 30918335 Free PMC article.
Oncolytic HSV-1 for the treatment of brain tumours.
Markert JM, Parker JN, Buchsbaum DJ, Grizzle WE, Gillespie GY, Whitley RJ. Markert JM, et al. Among authors: whitley rj. Herpes. 2006 Nov;13(3):66-71. Herpes. 2006. PMID: 17147910 Review.
Design and Rationale for First-in-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors.
Bernstock JD, Bag AK, Fiveash J, Kachurak K, Elsayed G, Chagoya G, Gessler F, Valdes PA, Madan-Swain A, Whitley R, Markert JM, Gillespie GY, Johnston JM, Friedman GK. Bernstock JD, et al. Hum Gene Ther. 2020 Oct;31(19-20):1132-1139. doi: 10.1089/hum.2020.101. Epub 2020 Aug 17. Hum Gene Ther. 2020. PMID: 32657154 Free PMC article.
429 results