Sears R - Search Results

1

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.

Phesse TJ, Myant KB, Cole AM, Ridgway RA, Pearson H, Muncan V, van den Brink GR, Vousden KH, Sears R, Vassilev LT, Clarke AR, Sansom OJ. Phesse TJ, et al. Among authors: sears r. Cell Death Differ. 2014 Jun;21(6):956-66. doi: 10.1038/cdd.2014.15. Epub 2014 Feb 28. Cell Death Differ. 2014. PMID: 24583641 Free PMC article.

2

Myc requires distinct E2F activities to induce S phase and apoptosis.

Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR. Leone G, et al. Among authors: sears r. Mol Cell. 2001 Jul;8(1):105-13. doi: 10.1016/s1097-2765(01)00275-1. Mol Cell. 2001. PMID: 11511364 Free article.

3

Inhibition of c-Myc activity by ribosomal protein L11.

Dai MS, Arnold H, Sun XX, Sears R, Lu H. Dai MS, et al. Among authors: sears r. EMBO J. 2007 Jul 25;26(14):3332-45. doi: 10.1038/sj.emboj.7601776. Epub 2007 Jun 28. EMBO J. 2007. PMID: 17599065 Free PMC article.

4

A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.

Arnold HK, Sears RC. Arnold HK, et al. Cancer Metastasis Rev. 2008 Jun;27(2):147-58. doi: 10.1007/s10555-008-9128-9. Cancer Metastasis Rev. 2008. PMID: 18246411 Free PMC article. Review.

5

The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.

Escamilla-Powers JR, Daniel CJ, Farrell A, Taylor K, Zhang X, Byers S, Sears R. Escamilla-Powers JR, et al. Among authors: sears r. J Biol Chem. 2010 Feb 12;285(7):4847-58. doi: 10.1074/jbc.M109.074856. Epub 2009 Dec 11. J Biol Chem. 2010. PMID: 20008325 Free PMC article.

6

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ. Ashton GH, et al. Among authors: sears rc. Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015. Dev Cell. 2010. PMID: 20708588 Free PMC article.

7

Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.

Wang X, Cunningham M, Zhang X, Tokarz S, Laraway B, Troxell M, Sears RC. Wang X, et al. Cancer Res. 2011 Feb 1;71(3):925-36. doi: 10.1158/0008-5472.CAN-10-1032. Epub 2011 Jan 25. Cancer Res. 2011. PMID: 21266350 Free PMC article.

8

Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression.

Zhang X, Farrell AS, Daniel CJ, Arnold H, Scanlan C, Laraway BJ, Janghorban M, Lum L, Chen D, Troxell M, Sears R. Zhang X, et al. Among authors: sears r. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2790-5. doi: 10.1073/pnas.1100764108. Epub 2011 Aug 1. Proc Natl Acad Sci U S A. 2012. PMID: 21808024 Free PMC article.

9

Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.

Farrell AS, Pelz C, Wang X, Daniel CJ, Wang Z, Su Y, Janghorban M, Zhang X, Morgan C, Impey S, Sears RC. Farrell AS, et al. Mol Cell Biol. 2013 Aug;33(15):2930-49. doi: 10.1128/MCB.01455-12. Epub 2013 May 28. Mol Cell Biol. 2013. PMID: 23716601 Free PMC article.

10

Detection of c-Myc protein-protein interactions and phosphorylation status by immunoprecipitation.

Daniel CJ, Zhang X, Sears RC. Daniel CJ, et al. Methods Mol Biol. 2013;1012:65-76. doi: 10.1007/978-1-62703-429-6_5. Methods Mol Biol. 2013. PMID: 24006058

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