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Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B. Roncagalli R, et al. Nat Immunol. 2014 Apr;15(4):384-392. doi: 10.1038/ni.2843. Epub 2014 Mar 2. Nat Immunol. 2014. PMID: 24584089 Free PMC article.
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B. Mingueneau M, et al. Among authors: roncagalli r. Immunity. 2009 Aug 21;31(2):197-208. doi: 10.1016/j.immuni.2009.05.013. Epub 2009 Aug 13. Immunity. 2009. PMID: 19682930 Free article.
Proteomic analysis of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) interactome in resting and activated primary mast cells [corrected].
Bounab Y, Hesse AM, Iannascoli B, Grieco L, Couté Y, Niarakis A, Roncagalli R, Lie E, Lam KP, Demangel C, Thieffry D, Garin J, Malissen B, Daëron M. Bounab Y, et al. Among authors: roncagalli r. Mol Cell Proteomics. 2013 Oct;12(10):2874-89. doi: 10.1074/mcp.M112.025908. Epub 2013 Jul 2. Mol Cell Proteomics. 2013. PMID: 23820730 Free PMC article.
The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells.
Giordano M, Roncagalli R, Bourdely P, Chasson L, Buferne M, Yamasaki S, Beyaert R, van Loo G, Auphan-Anezin N, Schmitt-Verhulst AM, Verdeil G. Giordano M, et al. Among authors: roncagalli r. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11115-20. doi: 10.1073/pnas.1406259111. Epub 2014 Jul 14. Proc Natl Acad Sci U S A. 2014. PMID: 25024217 Free PMC article.
39 results