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SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites.
Hemachandra LP, Patel H, Chandrasena RE, Choi J, Piyankarage SC, Wang S, Wang Y, Thayer EN, Scism RA, Michalsen BT, Xiong R, Siklos MI, Bolton JL, Thatcher GR. Hemachandra LP, et al. Cancer Prev Res (Phila). 2014 May;7(5):505-15. doi: 10.1158/1940-6207.CAPR-13-0296. Epub 2014 Mar 5. Cancer Prev Res (Phila). 2014. PMID: 24598415 Free PMC article.
Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).
Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen SN, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL. Hemachandra LP, et al. Cancer Prev Res (Phila). 2012 Jan;5(1):73-81. doi: 10.1158/1940-6207.CAPR-11-0348. Epub 2011 Oct 13. Cancer Prev Res (Phila). 2012. PMID: 21997247 Free PMC article.