Chen Y - Search Results

1

Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies.

Zhang W, Gao C, Konopleva M, Chen Y, Jacamo RO, Borthakur G, Cortes JE, Ravandi F, Ramachandran A, Andreeff M. Zhang W, et al. Among authors: chen y. Clin Cancer Res. 2014 May 1;20(9):2363-74. doi: 10.1158/1078-0432.CCR-13-2052. Epub 2014 Mar 11. Clin Cancer Res. 2014. PMID: 24619500 Free PMC article.

2

p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12.

Kojima K, McQueen T, Chen Y, Jacamo R, Konopleva M, Shinojima N, Shpall E, Huang X, Andreeff M. Kojima K, et al. Among authors: chen y. Blood. 2011 Oct 20;118(16):4431-9. doi: 10.1182/blood-2011-02-334136. Epub 2011 Aug 25. Blood. 2011. PMID: 21868571 Free PMC article.

3

CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia.

Chen Y, Jacamo R, Konopleva M, Garzon R, Croce C, Andreeff M. Chen Y, et al. J Clin Invest. 2013 Jun;123(6):2395-407. doi: 10.1172/JCI66553. Epub 2013 May 8. J Clin Invest. 2013. PMID: 23676502 Free PMC article.

4

The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations.

Zhang W, Borthakur G, Gao C, Chen Y, Mu H, Ruvolo VR, Nomoto K, Zhao N, Konopleva M, Andreeff M. Zhang W, et al. Among authors: chen y. Cancer Res. 2016 Mar 15;76(6):1528-37. doi: 10.1158/0008-5472.CAN-15-1580. Epub 2016 Jan 28. Cancer Res. 2016. PMID: 26822154 Free PMC article.

5

The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo.

Ling X, Spaeth E, Chen Y, Shi Y, Zhang W, Schober W, Hail N Jr, Konopleva M, Andreeff M. Ling X, et al. Among authors: chen y. PLoS One. 2013;8(3):e58426. doi: 10.1371/journal.pone.0058426. Epub 2013 Mar 6. PLoS One. 2013. PMID: 23484027 Free PMC article.

6

Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth.

Lu H, Kojima K, Battula VL, Korchin B, Shi Y, Chen Y, Spong S, Thomas DA, Kantarjian H, Lock RB, Andreeff M, Konopleva M. Lu H, et al. Among authors: chen y. Ann Hematol. 2014 Mar;93(3):485-492. doi: 10.1007/s00277-013-1939-2. Epub 2013 Oct 24. Ann Hematol. 2014. PMID: 24154679 Free PMC article.

7

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance.

Jacamo R, Chen Y, Wang Z, Ma W, Zhang M, Spaeth EL, Wang Y, Battula VL, Mak PY, Schallmoser K, Ruvolo P, Schober WD, Shpall EJ, Nguyen MH, Strunk D, Bueso-Ramos CE, Konoplev S, Davis RE, Konopleva M, Andreeff M. Jacamo R, et al. Among authors: chen y. Blood. 2014 Apr 24;123(17):2691-702. doi: 10.1182/blood-2013-06-511527. Epub 2014 Mar 5. Blood. 2014. PMID: 24599548 Free PMC article.

8

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network.

Carter BZ, Mak PY, Chen Y, Mak DH, Mu H, Jacamo R, Ruvolo V, Arold ST, Ladbury JE, Burks JK, Kornblau S, Andreeff M. Carter BZ, et al. Among authors: chen y. Oncotarget. 2016 Apr 12;7(15):20054-67. doi: 10.18632/oncotarget.7911. Oncotarget. 2016. PMID: 26956049 Free PMC article.

9

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment.

Chen Y, Jacamo R, Shi YX, Wang RY, Battula VL, Konoplev S, Strunk D, Hofmann NA, Reinisch A, Konopleva M, Andreeff M. Chen Y, et al. Blood. 2012 May 24;119(21):4971-80. doi: 10.1182/blood-2011-11-389957. Epub 2012 Apr 5. Blood. 2012. PMID: 22490334 Free PMC article.

10

Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment.

Battula VL, Chen Y, Cabreira Mda G, Ruvolo V, Wang Z, Ma W, Konoplev S, Shpall E, Lyons K, Strunk D, Bueso-Ramos C, Davis RE, Konopleva M, Andreeff M. Battula VL, et al. Among authors: chen y. Blood. 2013 Jul 18;122(3):357-66. doi: 10.1182/blood-2012-06-437988. Epub 2013 Jun 5. Blood. 2013. PMID: 23741006 Free PMC article.

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