Wang Q - Search Results

1

Crenolanib is a selective type I pan-FLT3 inhibitor.

Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP. Smith CC, et al. Among authors: wang q. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24. doi: 10.1073/pnas.1320661111. Epub 2014 Mar 12. Proc Natl Acad Sci U S A. 2014. PMID: 24623852 Free PMC article.

2

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.

Smith CC, Wang Q, Chin CS, Salerno S, Damon LE, Levis MJ, Perl AE, Travers KJ, Wang S, Hunt JP, Zarrinkar PP, Schadt EE, Kasarskis A, Kuriyan J, Shah NP. Smith CC, et al. Among authors: wang s, wang q. Nature. 2012 Apr 15;485(7397):260-3. doi: 10.1038/nature11016. Nature. 2012. PMID: 22504184 Free PMC article.

3

Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220).

Zorn JA, Wang Q, Fujimura E, Barros T, Kuriyan J. Zorn JA, et al. Among authors: wang q. PLoS One. 2015 Apr 2;10(4):e0121177. doi: 10.1371/journal.pone.0121177. eCollection 2015. PLoS One. 2015. PMID: 25837374 Free PMC article.

4

Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.

Chung JK, Nocka LM, Decker A, Wang Q, Kadlecek TA, Weiss A, Kuriyan J, Groves JT. Chung JK, et al. Among authors: wang q. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10798-10803. doi: 10.1073/pnas.1819309116. Epub 2019 May 10. Proc Natl Acad Sci U S A. 2019. PMID: 31076553 Free PMC article.

5

A structural atlas of kinases inhibited by clinically approved drugs.

Wang Q, Zorn JA, Kuriyan J. Wang Q, et al. Methods Enzymol. 2014;548:23-67. doi: 10.1016/B978-0-12-397918-6.00002-1. Methods Enzymol. 2014. PMID: 25399641 Review.

6

A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation.

Engel K, Sasaki T, Wang Q, Kuriyan J. Engel K, et al. Among authors: wang q. Biochem J. 2013 Aug 1;453(3):337-44. doi: 10.1042/BJ20130537. Biochem J. 2013. PMID: 23734957 Free PMC article.

7

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.

Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J. Shah NH, et al. Among authors: wang q. Elife. 2016 Oct 4;5:e20105. doi: 10.7554/eLife.20105. Elife. 2016. PMID: 27700984 Free PMC article.

8

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.

Kovacs E, Das R, Wang Q, Collier TS, Cantor A, Huang Y, Wong K, Mirza A, Barros T, Grob P, Jura N, Bose R, Kuriyan J. Kovacs E, et al. Among authors: wang q. Mol Cell Biol. 2015 Sep 1;35(17):3083-102. doi: 10.1128/MCB.00248-15. Epub 2015 Jun 29. Mol Cell Biol. 2015. PMID: 26124280 Free PMC article.

9

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.

Wang Q, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, Kuriyan J. Wang Q, et al. Elife. 2015 Feb 20;4:e06074. doi: 10.7554/eLife.06074. Elife. 2015. PMID: 25699547 Free PMC article.

10

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.

Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Mukherjee S, et al. Among authors: wang q. Sci Signal. 2013 Jan 1;6(256):ra1. doi: 10.1126/scisignal.2003220. Sci Signal. 2013. PMID: 23281368 Free PMC article.

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