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Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.
Yi P, Higa A, Taouji S, Bexiga MG, Marza E, Arma D, Castain C, Le Bail B, Simpson JC, Rosenbaum J, Balabaud C, Bioulac-Sage P, Blanc JF, Chevet E. Yi P, et al. Among authors: higa a. Mol Cancer Ther. 2012 Dec;11(12):2610-20. doi: 10.1158/1535-7163.MCT-12-0516. Epub 2012 Oct 5. Mol Cancer Ther. 2012. PMID: 23041544
Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα.
Pluquet O, Dejeans N, Bouchecareilh M, Lhomond S, Pineau R, Higa A, Delugin M, Combe C, Loriot S, Cubel G, Dugot-Senant N, Vital A, Loiseau H, Gosline SJ, Taouji S, Hallett M, Sarkaria JN, Anderson K, Wu W, Rodriguez FJ, Rosenbaum J, Saltel F, Fernandez-Zapico ME, Chevet E. Pluquet O, et al. Among authors: higa a. Cancer Res. 2013 Aug 1;73(15):4732-43. doi: 10.1158/0008-5472.CAN-12-3989. Epub 2013 Jun 10. Cancer Res. 2013. PMID: 23752693 Free PMC article.
Alterations of EDEM1 functions enhance ATF6 pro-survival signaling.
Papaioannou A, Higa A, Jégou G, Jouan F, Pineau R, Saas L, Avril T, Pluquet O, Chevet E. Papaioannou A, et al. Among authors: higa a. FEBS J. 2018 Nov;285(22):4146-4164. doi: 10.1111/febs.14669. Epub 2018 Oct 20. FEBS J. 2018. PMID: 30281916 Free article.
Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions.
Pepin E, Higa A, Schuster-Klein C, Bernard C, Sulpice T, Guardiola B, Chevet E, Alquier T. Pepin E, et al. Among authors: higa a. PLoS One. 2014 Nov 10;9(11):e112714. doi: 10.1371/journal.pone.0112714. eCollection 2014. PLoS One. 2014. PMID: 25383781 Free PMC article.
151 results