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The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.
Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ. Pekovic-Vaughan V, et al. Among authors: yang n. Genes Dev. 2014 Mar 15;28(6):548-60. doi: 10.1101/gad.237081.113. Genes Dev. 2014. PMID: 24637114 Free PMC article.
Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway.
Guo B, Yang N, Borysiewicz E, Dudek M, Williams JL, Li J, Maywood ES, Adamson A, Hastings MH, Bateman JF, White MR, Boot-Handford RP, Meng QJ. Guo B, et al. Among authors: yang n. Osteoarthritis Cartilage. 2015 Nov;23(11):1981-8. doi: 10.1016/j.joca.2015.02.020. Osteoarthritis Cartilage. 2015. PMID: 26521744 Free PMC article.
Cellular mechano-environment regulates the mammary circadian clock.
Yang N, Williams J, Pekovic-Vaughan V, Wang P, Olabi S, McConnell J, Gossan N, Hughes A, Cheung J, Streuli CH, Meng QJ. Yang N, et al. Nat Commun. 2017 Jan 30;8:14287. doi: 10.1038/ncomms14287. Nat Commun. 2017. PMID: 28134247 Free PMC article.
Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.
Yang N, Smyllie NJ, Morris H, Gonçalves CF, Dudek M, Pathiranage DRJ, Chesham JE, Adamson A, Spiller DG, Zindy E, Bagnall J, Humphreys N, Hoyland J, Loudon ASI, Hastings MH, Meng QJ. Yang N, et al. PLoS Genet. 2020 Apr 30;16(4):e1008729. doi: 10.1371/journal.pgen.1008729. eCollection 2020 Apr. PLoS Genet. 2020. PMID: 32352975 Free PMC article.
The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration.
Dudek M, Yang N, Ruckshanthi JP, Williams J, Borysiewicz E, Wang P, Adamson A, Li J, Bateman JF, White MR, Boot-Handford RP, Hoyland JA, Meng QJ. Dudek M, et al. Among authors: yang n. Ann Rheum Dis. 2017 Mar;76(3):576-584. doi: 10.1136/annrheumdis-2016-209428. Epub 2016 Aug 3. Ann Rheum Dis. 2017. PMID: 27489225 Free PMC article.
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity.
Dudek M, Gossan N, Yang N, Im HJ, Ruckshanthi JP, Yoshitane H, Li X, Jin D, Wang P, Boudiffa M, Bellantuono I, Fukada Y, Boot-Handford RP, Meng QJ. Dudek M, et al. Among authors: yang n. J Clin Invest. 2016 Jan;126(1):365-76. doi: 10.1172/JCI82755. Epub 2015 Dec 14. J Clin Invest. 2016. PMID: 26657859 Free PMC article.
6,988 results