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Decreased clearance of CNS beta-amyloid in Alzheimer's disease.
Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ. Mawuenyega KG, et al. Among authors: ovod v. Science. 2010 Dec 24;330(6012):1774. doi: 10.1126/science.1197623. Epub 2010 Dec 9. Science. 2010. PMID: 21148344 Free PMC article.
Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers.
Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, Mawuenyega K, Blazey T, Goate A, Chott R, Yarasheski KE, Holtzman DM, Morris JC, Benzinger TL, Bateman RJ. Potter R, et al. Among authors: ovod v. Sci Transl Med. 2013 Jun 12;5(189):189ra77. doi: 10.1126/scitranslmed.3005615. Sci Transl Med. 2013. PMID: 23761040 Free PMC article.
CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.
Dobrowolska JA, Michener MS, Wu G, Patterson BW, Chott R, Ovod V, Pyatkivskyy Y, Wildsmith KR, Kasten T, Mathers P, Dancho M, Lennox C, Smith BE, Gilberto D, McLoughlin D, Holder DJ, Stamford AW, Yarasheski KE, Kennedy ME, Savage MJ, Bateman RJ. Dobrowolska JA, et al. Among authors: ovod v. J Neurosci. 2014 Jun 11;34(24):8336-46. doi: 10.1523/JNEUROSCI.0540-14.2014. J Neurosci. 2014. PMID: 24920637 Free PMC article.
Amyloid-β efflux from the central nervous system into the plasma.
Roberts KF, Elbert DL, Kasten TP, Patterson BW, Sigurdson WC, Connors RE, Ovod V, Munsell LY, Mawuenyega KG, Miller-Thomas MM, Moran CJ, Cross DT 3rd, Derdeyn CP, Bateman RJ. Roberts KF, et al. Among authors: ovod v. Ann Neurol. 2014 Dec;76(6):837-44. doi: 10.1002/ana.24270. Epub 2014 Oct 24. Ann Neurol. 2014. PMID: 25205593 Free PMC article.
Age and amyloid effects on human central nervous system amyloid-beta kinetics.
Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, Bateman RJ. Patterson BW, et al. Among authors: ovod v. Ann Neurol. 2015 Sep;78(3):439-53. doi: 10.1002/ana.24454. Epub 2015 Jul 20. Ann Neurol. 2015. PMID: 26040676 Free PMC article.
Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma.
Baker-Nigh AT, Mawuenyega KG, Bollinger JG, Ovod V, Kasten T, Franklin EE, Liao F, Jiang H, Holtzman D, Cairns NJ, Morris JC, Bateman RJ. Baker-Nigh AT, et al. Among authors: ovod v. J Biol Chem. 2016 Dec 30;291(53):27204-27218. doi: 10.1074/jbc.M116.721779. Epub 2016 Oct 28. J Biol Chem. 2016. PMID: 27793990 Free PMC article.
Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis.
Ovod V, Ramsey KN, Mawuenyega KG, Bollinger JG, Hicks T, Schneider T, Sullivan M, Paumier K, Holtzman DM, Morris JC, Benzinger T, Fagan AM, Patterson BW, Bateman RJ. Ovod V, et al. Alzheimers Dement. 2017 Aug;13(8):841-849. doi: 10.1016/j.jalz.2017.06.2266. Epub 2017 Jul 19. Alzheimers Dement. 2017. PMID: 28734653 Free PMC article.
65 results