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Decreased clearance of CNS beta-amyloid in Alzheimer's disease.
Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ. Mawuenyega KG, et al. Among authors: sigurdson w. Science. 2010 Dec 24;330(6012):1774. doi: 10.1126/science.1197623. Epub 2010 Dec 9. Science. 2010. PMID: 21148344 Free PMC article.
Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease.
Portelius E, Zetterberg H, Dean RA, Marcil A, Bourgeois P, Nutu M, Andreasson U, Siemers E, Mawuenyega KG, Sigurdson WC, May PC, Paul SM, Holtzman DM, Blennow K, Bateman RJ. Portelius E, et al. J Alzheimers Dis. 2012;31(2):335-41. doi: 10.3233/JAD-2012-120508. J Alzheimers Dis. 2012. PMID: 22531418 Free PMC article. Clinical Trial.
In vivo human apolipoprotein E isoform fractional turnover rates in the CNS.
Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, Yarasheski KE, Wang JX, Mawuenyega KG, Jiang H, Parsadanian M, Yoon H, Kasten T, Sigurdson WC, Xiong C, Goate A, Holtzman DM, Bateman RJ. Wildsmith KR, et al. Among authors: sigurdson wc. PLoS One. 2012;7(6):e38013. doi: 10.1371/journal.pone.0038013. Epub 2012 Jun 4. PLoS One. 2012. PMID: 22675504 Free PMC article.
β-amyloid dynamics in human plasma.
Huang Y, Potter R, Sigurdson W, Kasten T, Connors R, Morris JC, Benzinger T, Mintun M, Ashwood T, Ferm M, Budd SL, Bateman RJ. Huang Y, et al. Among authors: sigurdson w. Arch Neurol. 2012 Dec;69(12):1591-7. doi: 10.1001/archneurol.2012.18107. Arch Neurol. 2012. PMID: 23229043 Free PMC article.
Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers.
Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, Mawuenyega K, Blazey T, Goate A, Chott R, Yarasheski KE, Holtzman DM, Morris JC, Benzinger TL, Bateman RJ. Potter R, et al. Among authors: sigurdson w. Sci Transl Med. 2013 Jun 12;5(189):189ra77. doi: 10.1126/scitranslmed.3005615. Sci Transl Med. 2013. PMID: 23761040 Free PMC article.
Amyloid-β efflux from the central nervous system into the plasma.
Roberts KF, Elbert DL, Kasten TP, Patterson BW, Sigurdson WC, Connors RE, Ovod V, Munsell LY, Mawuenyega KG, Miller-Thomas MM, Moran CJ, Cross DT 3rd, Derdeyn CP, Bateman RJ. Roberts KF, et al. Among authors: sigurdson wc. Ann Neurol. 2014 Dec;76(6):837-44. doi: 10.1002/ana.24270. Epub 2014 Oct 24. Ann Neurol. 2014. PMID: 25205593 Free PMC article.
55 results