Anand K - Search Results

1

The structure and substrate specificity of human Cdk12/Cyclin K.

Bösken CA, Farnung L, Hintermair C, Merzel Schachter M, Vogel-Bachmayr K, Blazek D, Anand K, Fisher RP, Eick D, Geyer M. Bösken CA, et al. Among authors: anand k. Nat Commun. 2014 Mar 24;5:3505. doi: 10.1038/ncomms4505. Nat Commun. 2014. PMID: 24662513 Free PMC article.

2

Cyclin box structure of the P-TEFb subunit cyclin T1 derived from a fusion complex with EIAV tat.

Anand K, Schulte A, Fujinaga K, Scheffzek K, Geyer M. Anand K, et al. J Mol Biol. 2007 Jul 27;370(5):826-36. doi: 10.1016/j.jmb.2007.04.077. Epub 2007 May 10. J Mol Biol. 2007. PMID: 17540406 Free PMC article.

3

Structural insights into the cyclin T1-Tat-TAR RNA transcription activation complex from EIAV.

Anand K, Schulte A, Vogel-Bachmayr K, Scheffzek K, Geyer M. Anand K, et al. Nat Struct Mol Biol. 2008 Dec;15(12):1287-92. doi: 10.1038/nsmb.1513. Epub 2008 Nov 23. Nat Struct Mol Biol. 2008. PMID: 19029897

4

Formation of Tat-TAR containing ribonucleoprotein complexes for biochemical and structural analyses.

Bigalke JM, Czudnochowski N, Vollmuth F, Vogel-Bachmayr K, Anand K, Geyer M. Bigalke JM, et al. Among authors: anand k. Methods. 2011 Jan;53(1):78-84. doi: 10.1016/j.ymeth.2010.04.001. Epub 2010 Apr 10. Methods. 2011. PMID: 20385237

5

Structural and Functional Analysis of the Cdk13/Cyclin K Complex.

Greifenberg AK, Hönig D, Pilarova K, Düster R, Bartholomeeusen K, Bösken CA, Anand K, Blazek D, Geyer M. Greifenberg AK, et al. Among authors: anand k. Cell Rep. 2016 Jan 12;14(2):320-31. doi: 10.1016/j.celrep.2015.12.025. Epub 2015 Dec 31. Cell Rep. 2016. PMID: 26748711 Free article.

6

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.

Manrique S, Sauter D, Horenkamp FA, Lülf S, Yu H, Hotter D, Anand K, Kirchhoff F, Geyer M. Manrique S, et al. Among authors: anand k. Nat Commun. 2017 Sep 5;8(1):442. doi: 10.1038/s41467-017-00481-z. Nat Commun. 2017. PMID: 28874665 Free PMC article.

7

Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.

Marleaux M, Anand K, Latz E, Geyer M. Marleaux M, et al. Among authors: anand k. FEBS Lett. 2020 Aug;594(15):2383-2395. doi: 10.1002/1873-3468.13865. Epub 2020 Jul 6. FEBS Lett. 2020. PMID: 32542665 Free article.

8

Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.

Jiang B, Jiang J, Kaltheuner IH, Iniguez AB, Anand K, Ferguson FM, Ficarro SB, Seong BKA, Greifenberg AK, Dust S, Kwiatkowski NP, Marto JA, Stegmaier K, Zhang T, Geyer M, Gray NS. Jiang B, et al. Among authors: anand k. Eur J Med Chem. 2021 Oct 5;221:113481. doi: 10.1016/j.ejmech.2021.113481. Epub 2021 Apr 20. Eur J Med Chem. 2021. PMID: 33945934

9

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.

Kaltheuner IH, Anand K, Moecking J, Düster R, Wang J, Gray NS, Geyer M. Kaltheuner IH, et al. Among authors: anand k. Nat Commun. 2021 Nov 16;12(1):6607. doi: 10.1038/s41467-021-26935-z. Nat Commun. 2021. PMID: 34785661 Free PMC article.

10

The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation.

Schmitz M, Kaltheuner IH, Anand K, Düster R, Moecking J, Monastyrskyi A, Duckett DR, Roush WR, Geyer M. Schmitz M, et al. Among authors: anand k. J Biol Chem. 2024 Jan;300(1):105501. doi: 10.1016/j.jbc.2023.105501. Epub 2023 Nov 26. J Biol Chem. 2024. PMID: 38016516 Free PMC article.

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