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Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.
Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA. Gehrig S, et al. Among authors: hirtz s. Am J Respir Crit Care Med. 2014 May 1;189(9):1082-92. doi: 10.1164/rccm.201311-1932OC. Am J Respir Crit Care Med. 2014. PMID: 24678594
Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema.
Trojanek JB, Cobos-Correa A, Diemer S, Kormann M, Schubert SC, Zhou-Suckow Z, Agrawal R, Duerr J, Wagner CJ, Schatterny J, Hirtz S, Sommerburg O, Hartl D, Schultz C, Mall MA. Trojanek JB, et al. Among authors: hirtz s. Am J Respir Cell Mol Biol. 2014 Nov;51(5):709-20. doi: 10.1165/rcmb.2013-0407OC. Am J Respir Cell Mol Biol. 2014. PMID: 24828142
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