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CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2.
Boucheron N, Tschismarov R, Goeschl L, Moser MA, Lagger S, Sakaguchi S, Winter M, Lenz F, Vitko D, Breitwieser FP, Müller L, Hassan H, Bennett KL, Colinge J, Schreiner W, Egawa T, Taniuchi I, Matthias P, Seiser C, Ellmeier W. Boucheron N, et al. Among authors: seiser c. Nat Immunol. 2014 May;15(5):439-448. doi: 10.1038/ni.2864. Epub 2014 Mar 30. Nat Immunol. 2014. PMID: 24681565 Free PMC article.
The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.
Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C. Zupkovitz G, et al. Among authors: seiser c. Mol Cell Biol. 2010 Mar;30(5):1171-81. doi: 10.1128/MCB.01500-09. Epub 2009 Dec 22. Mol Cell Biol. 2010. PMID: 20028735 Free PMC article.
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production.
Grausenburger R, Bilic I, Boucheron N, Zupkovitz G, El-Housseiny L, Tschismarov R, Zhang Y, Rembold M, Gaisberger M, Hartl A, Epstein MM, Matthias P, Seiser C, Ellmeier W. Grausenburger R, et al. Among authors: seiser c. J Immunol. 2010 Sep 15;185(6):3489-97. doi: 10.4049/jimmunol.0903610. Epub 2010 Aug 11. J Immunol. 2010. PMID: 20702731 Free PMC article.
Protein acetylation and the physiological role of HDACs.
Matthias P, Seiser C, Yoshida M. Matthias P, et al. Among authors: seiser c. J Biomed Biotechnol. 2011;2011:148201. doi: 10.1155/2011/148201. Epub 2011 Oct 25. J Biomed Biotechnol. 2011. PMID: 22500071 Free PMC article. No abstract available.
91 results