Chan TH - Search Results

1

In vitro and in vivo efficacy of novel flavonoid dimers against cutaneous leishmaniasis.

Wong IL, Chan KF, Chen YF, Lun ZR, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. Antimicrob Agents Chemother. 2014 Jun;58(6):3379-88. doi: 10.1128/AAC.02425-13. Epub 2014 Mar 31. Antimicrob Agents Chemother. 2014. PMID: 24687505 Free PMC article.

2

A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.

Yan CS, Wong IL, Chan KF, Kan JW, Chong TC, Law MC, Zhao Y, Chan SW, Chan TH, Chow LM. Yan CS, et al. Among authors: chan kf, chan sw, chan th. Mol Pharm. 2015 Oct 5;12(10):3507-17. doi: 10.1021/mp500770e. Epub 2015 Aug 27. Mol Pharm. 2015. PMID: 26291333

3

Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".

Wong ILK, Zhu X, Chan KF, Law MC, Lo AMY, Hu X, Chow LMC, Chan TH. Wong ILK, et al. Among authors: chan kf, chan th. J Med Chem. 2018 Nov 21;61(22):9931-9951. doi: 10.1021/acs.jmedchem.8b00834. Epub 2018 Nov 1. J Med Chem. 2018. PMID: 30351934

4

Amine-Linked Flavonoids as Agents Against Cutaneous Leishmaniasis.

Chan CF, Liu Z, Wong ILK, Zhao X, Yang Z, Zheng J, Lee MM, Chan MK, Chan TH, Chow LMC. Chan CF, et al. Among authors: chan mk, chan th. Antimicrob Agents Chemother. 2023 May 1;65(5):e02165-20. doi: 10.1128/AAC.02165-20. Epub 2021 Mar 8. Antimicrob Agents Chemother. 2023. PMID: 33685890 Free PMC article.

5

Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.

Wong IL, Chan KF, Burkett BA, Zhao Y, Chai Y, Sun H, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. Antimicrob Agents Chemother. 2007 Mar;51(3):930-40. doi: 10.1128/AAC.00998-06. Epub 2006 Dec 28. Antimicrob Agents Chemother. 2007. PMID: 17194831 Free PMC article.

6

Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships.

Chan KF, Zhao Y, Chow TW, Yan CS, Ma DL, Burkett BA, Wong IL, Chow LM, Chan TH. Chan KF, et al. Among authors: chan th. ChemMedChem. 2009 Apr;4(4):594-614. doi: 10.1002/cmdc.200800413. ChemMedChem. 2009. PMID: 19288491

7

Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.

Wong IL, Chan KF, Zhao Y, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. J Antimicrob Chemother. 2009 Jun;63(6):1179-90. doi: 10.1093/jac/dkp130. Epub 2009 Apr 17. J Antimicrob Chemother. 2009. PMID: 19377065

8

Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.

Chan KF, Wong IL, Kan JW, Yan CS, Chow LM, Chan TH. Chan KF, et al. Among authors: chan th. J Med Chem. 2012 Mar 8;55(5):1999-2014. doi: 10.1021/jm201121b. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22320402

9

Flavonoid dimers as novel, potent antileishmanial agents.

Wong IL, Chan KF, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. J Med Chem. 2012 Oct 25;55(20):8891-902. doi: 10.1021/jm301172v. Epub 2012 Oct 3. J Med Chem. 2012. PMID: 22989363

10

Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.

Dury L, Nasr R, Lorendeau D, Comsa E, Wong I, Zhu X, Chan KF, Chan TH, Chow L, Falson P, Di Pietro A, Baubichon-Cortay H. Dury L, et al. Among authors: chan kf, chan th. Biochem Pharmacol. 2017 Jan 15;124:10-18. doi: 10.1016/j.bcp.2016.10.013. Epub 2016 Oct 28. Biochem Pharmacol. 2017. PMID: 27984000

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