Gordeev MF - Search Results

1

New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile.

Gordeev MF, Yuan ZY. Gordeev MF, et al. J Med Chem. 2014 Jun 12;57(11):4487-97. doi: 10.1021/jm401931e. Epub 2014 Apr 16. J Med Chem. 2014. PMID: 24694071 Review.

2

Metabolism of MRX-I, a novel antibacterial oxazolidinone, in humans: the oxidative ring opening of 2,3-Dihydropyridin-4-one catalyzed by non-P450 enzymes.

Meng J, Zhong D, Li L, Yuan Z, Yuan H, Xie C, Zhou J, Li C, Gordeev MF, Liu J, Chen X. Meng J, et al. Among authors: gordeev mf. Drug Metab Dispos. 2015 May;43(5):646-59. doi: 10.1124/dmd.114.061747. Epub 2015 Feb 20. Drug Metab Dispos. 2015. PMID: 25710940

3

New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones.

Singh U, Raju B, Lam S, Zhou J, Gadwood RC, Ford CW, Zurenko GE, Schaadt RD, Morin SE, Adams WJ, Friis JM, Courtney M, Palandra J, Hackbarth CJ, Lopez S, Wu C, Mortell KH, Trias J, Yuan Z, Patel DV, Gordeev MF. Singh U, et al. Among authors: gordeev mf. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4209-12. doi: 10.1016/j.bmcl.2003.07.022. Bioorg Med Chem Lett. 2003. PMID: 14623003

4

Selection and characterisation of Staphylococcus aureus mutants with reduced susceptibility to the investigational oxazolidinone MRX-I.

Huang Y, Xu Y, Liu S, Wang H, Xu X, Guo Q, Wu B, Gordeev MF, Wang W, Yuan Z, Wang M. Huang Y, et al. Among authors: gordeev mf. Int J Antimicrob Agents. 2014 May;43(5):418-22. doi: 10.1016/j.ijantimicag.2014.02.008. Epub 2014 Mar 22. Int J Antimicrob Agents. 2014. PMID: 24721233

5

Discovery of Antibacterial Contezolid Acefosamil: Innovative O-Acyl Phosphoramidate Prodrug for IV and Oral Therapies.

Liu J, Wang W, Wang C, Zhang L, Zhang X, Liu S, Xu Y, Wang H, Dai Q, Liu C, Wang X, Yuan Z, Gordeev MF. Liu J, et al. Among authors: gordeev mf. ACS Med Chem Lett. 2022 Jun 29;13(7):1030-1035. doi: 10.1021/acsmedchemlett.2c00191. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859881 Free PMC article.

6

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones.

Renslo AR, Jaishankar P, Venkatachalam R, Hackbarth C, Lopez S, Patel DV, Gordeev MF. Renslo AR, et al. Among authors: gordeev mf. J Med Chem. 2005 Jul 28;48(15):5009-24. doi: 10.1021/jm058204j. J Med Chem. 2005. PMID: 16033280

7

Recent developments in the identification of novel oxazolidinone antibacterial agents.

Renslo AR, Luehr GW, Gordeev MF. Renslo AR, et al. Among authors: gordeev mf. Bioorg Med Chem. 2006 Jun 15;14(12):4227-40. doi: 10.1016/j.bmc.2006.01.068. Epub 2006 Mar 9. Bioorg Med Chem. 2006. PMID: 16527486 Review.

8

Short-term Safety, Tolerability, and Pharmacokinetics of MRX-I, an Oxazolidinone Antibacterial Agent, in Healthy Chinese Subjects.

Wu X, Li Y, Zhang J, Zhang Y, Yu J, Cao G, Chen Y, Guo B, Shi Y, Huang J, Cao Y, Liu X, Wu J, Gordeev MF, Yuan H, Wang W. Wu X, et al. Among authors: gordeev mf. Clin Ther. 2018 Feb;40(2):322-332.e5. doi: 10.1016/j.clinthera.2017.12.017. Epub 2018 Feb 2. Clin Ther. 2018. PMID: 29398160 Clinical Trial.

9

Novel oxazolidinone-quinolone hybrid antimicrobials.

Gordeev MF, Hackbarth C, Barbachyn MR, Banitt LS, Gage JR, Luehr GW, Gomez M, Trias J, Morin SE, Zurenko GE, Parker CN, Evans JM, White RJ, Patel DV. Gordeev MF, et al. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4213-6. doi: 10.1016/j.bmcl.2003.07.021. Bioorg Med Chem Lett. 2003. PMID: 14623004

10

Nonclinical Evaluation of Antibacterial Oxazolidinones Contezolid and Contezolid Acefosamil with Low Serotonergic Neurotoxicity.

Wang W, Voss KM, Liu J, Gordeev MF. Wang W, et al. Among authors: gordeev mf. Chem Res Toxicol. 2021 May 17;34(5):1348-1354. doi: 10.1021/acs.chemrestox.0c00524. Epub 2021 Apr 29. Chem Res Toxicol. 2021. PMID: 33913699

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