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Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.
Verhaegh W, van Ooijen H, Inda MA, Hatzis P, Versteeg R, Smid M, Martens J, Foekens J, van de Wiel P, Clevers H, van de Stolpe A. Verhaegh W, et al. Among authors: van ooijen h, van de wiel p, van de stolpe a. Cancer Res. 2014 Jun 1;74(11):2936-45. doi: 10.1158/0008-5472.CAN-13-2515. Epub 2014 Apr 2. Cancer Res. 2014. PMID: 24695361 Free article.
Knowledge-based computational models.
Verhaegh W, Van de Stolpe A. Verhaegh W, et al. Among authors: van de stolpe a. Oncotarget. 2014 Jul 30;5(14):5196-7. doi: 10.18632/oncotarget.2276. Oncotarget. 2014. PMID: 25114037 Free PMC article. No abstract available.
Tumor-Specific Mitochondrial DNA Variants Are Rarely Detected in Cell-Free DNA.
Weerts MJA, Timmermans EC, van de Stolpe A, Vossen RHAM, Anvar SY, Foekens JA, Sleijfer S, Martens JWM. Weerts MJA, et al. Among authors: van de stolpe a. Neoplasia. 2018 Jul;20(7):687-696. doi: 10.1016/j.neo.2018.05.003. Epub 2018 May 26. Neoplasia. 2018. PMID: 29842994 Free PMC article.
Assessment of Functional Phosphatidylinositol 3-Kinase Pathway Activity in Cancer Tissue Using Forkhead Box-O Target Gene Expression in a Knowledge-Based Computational Model.
van Ooijen H, Hornsveld M, Dam-de Veen C, Velter R, Dou M, Verhaegh W, Burgering B, van de Stolpe A. van Ooijen H, et al. Among authors: van de stolpe a. Am J Pathol. 2018 Sep;188(9):1956-1972. doi: 10.1016/j.ajpath.2018.05.020. Epub 2018 Jul 6. Am J Pathol. 2018. PMID: 30030980 Free article.
Author Correction: Pan-cancer subtyping in a 2D-map shows substructures that are driven by specific combinations of molecular characteristics.
Taskesen E, Huisman SMH, Mahfouz A, Krijthe JH, de Ridder J, van de Stolpe A, van den Akker E, Verhaegh W, Reinders MJT. Taskesen E, et al. Among authors: van den akker e, van de stolpe a, de ridder j. Sci Rep. 2018 Nov 23;8(1):17304. doi: 10.1038/s41598-018-35518-w. Sci Rep. 2018. PMID: 30470773 Free PMC article.
Estrogen Receptor Pathway Activity Score to Predict Clinical Response or Resistance to Neoadjuvant Endocrine Therapy in Primary Breast Cancer.
Inda MA, Blok EJ, Kuppen PJK, Charehbili A, den Biezen-Timmermans EC, van Brussel A, Fruytier SE, Meershoek-Klein Kranenbarg E, Kloet S, van der Burg B, Martens JWM, Sims AH, Turnbull AK, Dixon JM, Verhaegh W, Kroep JR, van de Velde CJH, van de Stolpe A. Inda MA, et al. Among authors: van de stolpe a, van brussel a, van der burg b, van de velde cjh. Mol Cancer Ther. 2020 Feb;19(2):680-689. doi: 10.1158/1535-7163.MCT-19-0318. Epub 2019 Nov 14. Mol Cancer Ther. 2020. PMID: 31727690
76 results